痛风方治疗湿热夹瘀型痛风临床观察

孙骏炜; 刘清平; 李楠; 吴豫云; 韩玉凤; 林昌松

doi:10.13422/j.cnki.syfjx.2017180186

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痛风方治疗湿热夹瘀型痛风临床观察

临床 | 更新时间：2024-01-04

- 痛风方治疗湿热夹瘀型痛风临床观察
- Effect of Tongfeng Decoction in Treating Gout with Moist Heat and Blood Stasis Syndrome
- 中国实验方剂学杂志 2017年23卷第18期页码：186-190
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家自然科学基金项目（81573930）
- DOI：10.13422/j.cnki.syfjx.2017180186
  中图分类号： R259
- 纸质出版日期：2017
- 稿件说明：
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孙骏炜, 刘清平, 李楠, 等. 痛风方治疗湿热夹瘀型痛风临床观察[J]. 中国实验方剂学杂志, 2017,23(18):186-190.

SUN Jun-wei, LIU Qing-ping, LI Nan, et al. Effect of Tongfeng Decoction in Treating Gout with Moist Heat and Blood Stasis Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(18): 186-190.
孙骏炜, 刘清平, 李楠, 等. 痛风方治疗湿热夹瘀型痛风临床观察[J]. 中国实验方剂学杂志, 2017,23(18):186-190. DOI： 10.13422/j.cnki.syfjx.2017180186.

SUN Jun-wei, LIU Qing-ping, LI Nan, et al. Effect of Tongfeng Decoction in Treating Gout with Moist Heat and Blood Stasis Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(18): 186-190. DOI： 10.13422/j.cnki.syfjx.2017180186.

摘要

目的：通过观察痛风方治疗湿热夹瘀型痛风患者的临床疗效，评价其有效性及安全性。方法：采用随机平行对照方法，将120例患者分为对照组和观察组，各60例，对照组给予口服塞来昔布胶囊0.2 g/次，2次/d。观察组在对照组基础上加服痛风方，1剂/d，两组患者疗程均为2周。分别记录治疗前和治疗后患者休息时关节肿痛分数，关节压痛分数，关节肿胀分数，总分数，关节肿痛指数，关节功能分级，C反应蛋白（CRP），血沉（ESR），D-二聚体（DD-i），血尿酸（UA）水平及生活质量评分（SF-36）的改变，并记录不良反应发生情况。结果：经治疗2周后，观察组临床有效率为87.27%，高于对照组的66.04%（χ2=7.536，P<0.05）；观察组休息时关节肿痛分数，关节压痛分数，总分数，关节功能评分，CRP，ESR，DD-i，UA均低于对照组（P<0.05）；观察组关节肿痛指数，生活质量SF-36评分均高于对照组（P<0.05）。两组患者不良事件发生率无统计学差异。结论：痛风方联合塞来昔布治疗湿热夹瘀型痛风性关节炎疗效确切，抗炎作用强，安全性好，且能降低血尿酸水平而不诱发痛风急性发作。

Abstract

Objective: To observe the effect of Tongfeng decoction in treating gout patients with moist heat and blood stasis syndrome treated

in order to evaluate the efficacy and safety of Tongfeng decoction in treating acute gout.Method: With a randomized

parallel-controlled approach

one hundred and twenty gout patients were divided into control group and observation group. Patients in control group were treated with celecoxib 0.2 g

twice a day. Patients in observation group were treated with celecoxib 0.2 g

twice a day

and combined with Tongfeng decoction

one dose a day. Both groups received therapy for 2 weeks. The changes in score of joint gall in rest

score of joint tenderness

score of joint swollen

gross score

index of joint gall

score of joint function

serum levels of C-reactive protein

erythrocyte sedimentation rate

D-dimer and uric acid

life quality (SF-36)

and adverse reactions were recorded.Result: After treating for two weeks

the total effective rate in observation group was 87.27%

which was superior to 66.04% in control group (χ2=7.536

P<0.05). The score of joint gall in rest

score of joint tenderness

score of joint swollen

gross score

score of joint function

serum levels of C-reactive protein

erythrocyte sedimentation rate

D-dimer and uric acid in observation group were lower than those in control group (P<0.05). Index of joint gall and life quality in observation group were higher than those in control group (P<0.05). The rate of adverse reactions between control group and observation group had no statistical difference.Conclusion: Tongfeng decoction combined with celecoxib shows a positive effect in treating gout patients with moist heat and blood stasis syndrome. The Tongfeng decoction has strong anti-inflammatory activity and security. It can reduce the serum level of uric acid

without inducing acute attack.

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