小儿治哮灵片对发作期小儿咳嗽变异性哮喘气道反应性的影响

郭洁; 刘洁云; 吴雅俊; 董金磊

doi:10.13422/j.cnki.syfjx.2017180204

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小儿治哮灵片对发作期小儿咳嗽变异性哮喘气道反应性的影响

临床 | 更新时间：2024-01-04

- 小儿治哮灵片对发作期小儿咳嗽变异性哮喘气道反应性的影响
- Effect of Xiaoer Zhixiaoling Tablets on Airway Reactivity of Cough Variant Asthma in Attack Period
- 中国实验方剂学杂志 2017年23卷第18期页码：204-209
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家自然科学基金项目（81301556）
- DOI：10.13422/j.cnki.syfjx.2017180204
  中图分类号： R272
- 纸质出版日期：2017
- 稿件说明：
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郭洁, 刘洁云, 吴雅俊, 等. 小儿治哮灵片对发作期小儿咳嗽变异性哮喘气道反应性的影响[J]. 中国实验方剂学杂志, 2017,23(18):204-209.

GUO Jie, LIU Jie-yun, WU Ya-jun, et al. Effect of Xiaoer Zhixiaoling Tablets on Airway Reactivity of Cough Variant Asthma in Attack Period[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(18): 204-209.
郭洁, 刘洁云, 吴雅俊, 等. 小儿治哮灵片对发作期小儿咳嗽变异性哮喘气道反应性的影响[J]. 中国实验方剂学杂志, 2017,23(18):204-209. DOI： 10.13422/j.cnki.syfjx.2017180204.

GUO Jie, LIU Jie-yun, WU Ya-jun, et al. Effect of Xiaoer Zhixiaoling Tablets on Airway Reactivity of Cough Variant Asthma in Attack Period[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(18): 204-209. DOI： 10.13422/j.cnki.syfjx.2017180204.

摘要

目的：评价小儿治哮灵片对发作期咳嗽变异性哮喘（CVA）的临床疗效及对气道反应性和慢性炎症反应的影响。方法：将170例发作期CVA患儿，采用区组随机按数字表法分为对照组和观察组各85例。两组患儿均采用布地奈德气雾剂+孟鲁司特钠咀嚼片进行治疗，观察组加服小儿治哮灵片。两组疗程均为4周，并进行16周的随访。进行日间咳嗽、夜间咳嗽情况和咳嗽视觉模拟（VAS）评分；进行治疗前后莱塞斯特咳嗽问卷（LCQ）评分和中医证候评分；记录咳嗽缓解时间和16周内的复发情况；进行治疗前后气道反应检测；进行治疗前后白细胞介素-4（IL-4），IL-5，IL-13，嗜酸性粒细胞（EOS）和血清免疫球蛋白（IgE）检测。结果：观察组中医疗效总有效率为93.59%，高于对照组的81.33%（χ2=5.281，P<0.05）；治疗后观察组患儿日间咳嗽、夜间咳嗽、咳嗽总积分及咳嗽VAS评分均低于对照组（P<0.01）；观察组平均咳嗽缓解时间短于对照组（P<0.01）；在16周的随访期中，观察组复发率为39.74%，低于对照组的61.33%（χ2=5.281，P<0.05），观察组平均复发次数低于对照组（P<0.01）；治疗后观察组LCQ量表2个维度评分和总分均高于对照组（P<0.01）；观察组患儿血清IL-4，IL-5，IL-13，总IgE和EOS水平均低于对照组（P<0.01）；观察组患儿最小诱发累积剂量（Dmin）和PD35水平均高于对照组（P<0.01）。结论：小儿治哮灵片治疗发作期咳嗽变异性哮喘，能进一步的缓解咳嗽等临床症状，提高患者的生活质量，并能降低复发频率，其作用机制可能是通过减轻气道炎症反应、降低气道高反应性来实现的。

Abstract

Objective: To evaluated the clinical efficacy of Xiaoer Zhixiaoling tablets on cough variant asthma (CVA) in attack period and its effect on airway reactivity and chronic inflammatory response.Method: One hundred and seventy patients with CVA in attack period were divided into control group and observation group by random number table

with 85 cases in each group. Patients in control group got budesonide aerosol and montelukast sodium chewable tablets. Patients in observation group were also given Xiaoer Zhixiaoling tablets. A course of treatment was four weeks. And a 16-week following-up visit were made. Daytime

nighttime coughing and cough visual analogue scale (VAS) were scored. Before and after treatment

Leicester cough questionnaire (LCQ) and symptoms of traditional Chinese medicine (TCM) were scored. Recurrence during the 16 weeks and cough remission time were recorded. Before and after treatment

airway reaction and levels of interleukin-4 (IL-4)

IL-5

IL-13

eosinophils (EOS) and serum IgE were also detected.Result: The total effect rate in observation group was 93.59%

which was higher than 81.33% in control group (χ2=5.281

P<0.05). After treatment

daytime cough

night cough and total cough scores and cough VAS were all lower than those in control group (P<0.01). Mean cough remission time in observation group was shorter than that in control group (P<0.01). During the 16-week follow-up visit

the recurrence rate in observation group was 39.74%

which was lower than 61.33% in control group (χ2=5.281

P<0.05)

and the average frequency were lower than those in control group (P<0.01). The two dimension scores of LCQ and the total score were higher than those in control group (P<0.01). And levels of IL-4

IL-5

IL-13

IgE and EOS were lower than those in control group (P<0.01). The minimum induced cumulative dose and PD35 were higher than those in control group (P<0.01).Conclusion: Xiaoer Zhixiaoling tablets have a certain effect on in treating cough variant asthma (CVA)

and can relieve symptom

improve the quality of life of the patients

and reduce recurrence frequency. Its mechanism of action may be realized by reducing airway inflammation and airway hyper-responsiveness.

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