Objective: To investigate the correlation between blood stasis syndrome (BBS) and the interleukin-6 (IL-6) gene promoter methylation state in the unstable angina (UA) patients. Method: Six BBS in patients or out patients from the Department of Cardiology

Guang'anmen Hospital of China Academy of Chinese Medical Sciences were recruited from February to May in 2015 as the test group

while 6 non BBS in patients or out patients were recruited as control group. The IL-6 gene promoter methylation states were detected by bisulfite and compared between two groups to analyze the correlation between BBS and gene promoter methylation state. Result: The methylation degree of BBS group was potentially higher than that of non BBS group on 7 sites from -1 118 to -826 bp before the transcription initiation site of IL-6

but with no statistically difference between the two groups; and there was no significant difference in the methylation degree on 4 sites from -1 471 to -1 184 bp before the transcription initiation site of IL-6 between two groups. Conclusion: It could be inferred that the methylation states of BBS group were potentially higher than those of non BBS group on IL-6 promoter

in part reflecting the essence of BBS.