醒脑静注射液治疗急性脑出血患者临床疗效及对血清炎症因子、氧化应激的影响

马征; 孙雅菲; 康玲伶; 房铭辉; 高燕军

doi:10.13422/j.cnki.syfjx.2017190186

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醒脑静注射液治疗急性脑出血患者临床疗效及对血清炎症因子、氧化应激的影响

临床 | 更新时间：2024-01-04

- 醒脑静注射液治疗急性脑出血患者临床疗效及对血清炎症因子、氧化应激的影响
- Curative Effect of Xingnaojing Injection in Treatment of Acute Cerebral Hemorrhage and Indexes of Serum Inflammatory Factors, Oxidative Stress
- 中国实验方剂学杂志 2017年23卷第19期页码：186-190
- 作者机构：
- 作者简介：
- 基金信息：
  
  承德市科技局科学技术研究与发展计划项目（201121055）
- DOI：10.13422/j.cnki.syfjx.2017190186
  中图分类号： R277.7
- 纸质出版日期：2017
- 稿件说明：
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马征, 孙雅菲, 康玲伶, 等. 醒脑静注射液治疗急性脑出血患者临床疗效及对血清炎症因子、氧化应激的影响[J]. 中国实验方剂学杂志, 2017,23(19):186-190.

MA Zheng, SUN Ya-fei, KANG Ling-ling, et al. Curative Effect of Xingnaojing Injection in Treatment of Acute Cerebral Hemorrhage and Indexes of Serum Inflammatory Factors, Oxidative Stress[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(19): 186-190.
马征, 孙雅菲, 康玲伶, 等. 醒脑静注射液治疗急性脑出血患者临床疗效及对血清炎症因子、氧化应激的影响[J]. 中国实验方剂学杂志, 2017,23(19):186-190. DOI： 10.13422/j.cnki.syfjx.2017190186.

MA Zheng, SUN Ya-fei, KANG Ling-ling, et al. Curative Effect of Xingnaojing Injection in Treatment of Acute Cerebral Hemorrhage and Indexes of Serum Inflammatory Factors, Oxidative Stress[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(19): 186-190. DOI： 10.13422/j.cnki.syfjx.2017190186.

摘要

目的：观察醒脑静注射液治疗急性脑出血的临床疗效，探讨其对患者血清炎症因子、氧化应激指标的影响。方法：选取本院2015年1月-2016年1月收治的108例急性脑出血患者作为研究对象，采取随机数字表将其分成两组患者，每组54例。两组患者均给予常规治疗，观察组联合给予醒脑静注射液治疗，比较两组患者临床疗效及治疗前后血清炎症因子、氧化应激指标水平变化情况。结果：治疗后，观察组总有效率为96.30%，较对照组（85.19%）明显上升（P<0.05）。与治疗前比较，两组患者治疗后美国国立卫生院卒中量表（NIHSS）评分明显下降，格拉斯哥昏迷量表（GCS）评分明显升高（P<0.05），观察组改善效果明显优于对照组（P<0.05）。与治疗前比较，两组患者治疗后血清白细胞介素-6（IL-6），高敏C反应蛋白（hs-CRP），肿瘤坏死因子-α（TNF-α）水平明显下降（P<0.05），治疗后观察组血清IL-6，hs-CRP，TNF-α水平均明显低于对照组（P<0.05）。与治疗前比较，两组患者治疗后血清丙二醛（MDA）水平明显下降，超氧歧化酶（SOD）水平明显上升（P<0.05），观察组改善更明显（P<0.05）。治疗后，与治疗前比较，两组患者中医证候积分均明显改善（P<0.05）；观察组中医证候积分低于对照组（P<0.05）。两组患者不良反应比较，差异无统计学意义。结论：醒脑静注射液治疗急性脑出血能有效缓解机体内炎症反应及氧化应激反应，减轻神经功能缺损，改善意识状态，疗效确切。

Abstract

Objective: To investigate the clinical efficacy of Xingnaojing injection in the treatment of acute cerebral hemorrhage

oxidative stress and serum inflammatory factors. Method: Totally 108 cases of acute cerebral hemorrhage patients treated in our hospital from January 2015 to January 2016 were selected as the study objects

and divided into two groups according to the random number table

with 54 in each group. The two groups of patients were given conventional treatment

and the observation group was treated with Xingnaojing injection. Clinical curative effect

changes of serum inflammatory factors and oxidative stress index level of two groups before and after the treatment were compared. Result: The total effective rate of observation group was 96.30%

which was significantly higher than 85.19% of control group (P<0.05). After the treatment

the National Institute of Health Stroke Scale (NIHSS) score of the two groups decreased significantly

while the Glasgow Coma scale (GCS) score significantly increased (P<0.05)

indicating a better improvement effect in observation group than control group (P<0.05). After the treatment

the serum levels of interleukin (IL)-6

high-sensitivity C-reaction protein (hs-CRP) and tumor necrosis factor-α (TNF-α) were significantly lower than those before the treatment in two groups (P<0.05)

and the levels of serum IL-6

hs-CRP and TNF-α in observation group were significantly lower than those in control group (P<0.05). After the treatment

the serum malondialdehyde (MDA) level of two groups decreased significantly

while the level of superoxide dismutase (SOD) increased significantly (P<0.05). The two indexes of oxidative stress improved more significantly in the observation group (P<0.05). Compared with before treatment

traditional Chinese medicine (TCM) syndrome score of two groups were significantly improved after treatment

with statistically significant differences (P<0.05). TCM syndrome score of observation group was lower than that of control group

with statistically significant differences (P<0.05). Adverse reactions of the two groups had no statistically significant difference. Conclusion: Xingnaojing injection can effectively alleviate the oxidative stress response and inflammatory response

reduce the neurological deficit and improve the state of consciousness

with an obvious curative effect in the treatment of acute brain.

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