参附养荣汤加味对病毒性心肌炎慢性期阴阳两虚证炎症因子的影响

董凤梅; 苏荏; 孙慧灵

doi:10.13422/j.cnki.syfjx.2017190191

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参附养荣汤加味对病毒性心肌炎慢性期阴阳两虚证炎症因子的影响

临床 | 更新时间：2024-01-04

- 参附养荣汤加味对病毒性心肌炎慢性期阴阳两虚证炎症因子的影响
- Effect of Modified Shenfu Yangrong Tang on Inflammatory Factor of Syndrome of Deficiency of Both Yin and Yang of Viral Myocarditis
- 中国实验方剂学杂志 2017年23卷第19期页码：191-195
- 作者机构：
- 作者简介：
- 基金信息：
  
  河南省科技厅科技攻关项目（2015zw057）
- DOI：10.13422/j.cnki.syfjx.2017190191
  中图分类号： R259
- 纸质出版日期：2017
- 稿件说明：
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董凤梅, 苏荏, 孙慧灵. 参附养荣汤加味对病毒性心肌炎慢性期阴阳两虚证炎症因子的影响[J]. 中国实验方剂学杂志, 2017,23(19):191-195.

DONG Feng-mei, SU Ren, SUN Hui-ling. Effect of Modified Shenfu Yangrong Tang on Inflammatory Factor of Syndrome of Deficiency of Both Yin and Yang of Viral Myocarditis[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(19): 191-195.
董凤梅, 苏荏, 孙慧灵. 参附养荣汤加味对病毒性心肌炎慢性期阴阳两虚证炎症因子的影响[J]. 中国实验方剂学杂志, 2017,23(19):191-195. DOI： 10.13422/j.cnki.syfjx.2017190191.

DONG Feng-mei, SU Ren, SUN Hui-ling. Effect of Modified Shenfu Yangrong Tang on Inflammatory Factor of Syndrome of Deficiency of Both Yin and Yang of Viral Myocarditis[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(19): 191-195. DOI： 10.13422/j.cnki.syfjx.2017190191.

摘要

目的：探讨参附养荣汤加味治疗病毒性心肌炎（VMC）慢性期的疗效及对患者血清中白细胞介素（IL）-17，IL-27，IL-6，IL-9和核转录因子（NF）-κB水平的影响。方法：将140例VMC患者随机按数字表法分为对照组和观察组各70例。对照组给予西医综合干预措施。观察组在对照组治疗的基础上给予参附养荣汤加味，1剂/d，早晚2次内服；两组患者连续治疗8周。比较两组患者阴阳两虚证症状评分、血清中心型游离脂肪酸结合蛋白（H-FABP）和肌钙蛋白I（cTnI）水平、总体疗效及不良反应发生。检测两组患者血清中IL-17，IL-27，IL-6，IL-9和NF-κB水平。结果：治疗后观察组阴阳两虚证症状（心悸、气短、肢冷畏寒、烦躁、喘促、汗多、浮肿）评分、血清中H-FABP和cTnI水平均明显低于对照组（P<0.01）；观察组的临床总有效率为91.18%，明显高于对照组76.12%（P<0.05）；观察组患者的头痛等不良反应发生率均少于对照组，其中恶心呕吐和腹泻明显少于对照组（P<0.05）；观察组治疗后血清中IL-17，IL-6，IL-9和NF-κB水平均明显低于对照组，IL-27高于对照组（P<0.01）。结论：在西医常规治疗的基础上，参附养荣汤加味对VMC慢性期患者发挥了良好疗效，且安全性好，调节血清IL-17，IL-27，IL-6，IL-9和NF-κB水平变化可能是其作用机制之一。

Abstract

Objective: To investigate the clinical efficacy of modified Shenfu Yangrong Tang in treating viral myocarditis (VMC) and observe its effects on serum levels of interleukin (IL)-17

IL-27

nuclear transcription factor (NF)-κ B

IL-6

and IL-9. Method: One hundred and forty patients with VMC were randomly divided into control group and observation group with 70 cases in each group. The patients in control group were treated with western medicine comprehensive intervention measures. Based on the treatment in control group

in patients in observation group were also treated with modified Shenfu Yangrong Tang

1dose/day and twice daily in morning and night. The treatment course was 8 weeks for both groups. Scores of syndrome of deficiency of both Yin and Yang

serum levels of serum central free fatty acid binding protein (H-FABP)

Troponin I (cTnI)

total efficacy and adverse reactions were compared between two groups. In addition

the levels of IL-17

IL-27

IL-6

IL-9 and NF-κ B in serum were detected in both groups. Result: After treatment

scores of syndrome of deficiency of both Yin and Yang (palpitate

breathe hard

limb cold and chills

dysphoria

panting

hidrosis

and edema)

serum levels of H-FABP and cTnI in observation group were significantly lower than those of control group (P<0.01). Total efficacy was 91.18% in observation group

higher than 76.12% in control group (P<0.05). The incidence of adverse reactions such as headache in the observation group was lower than that in the control group

and nausea

vomiting and diarrhea were significantly less than those in the control group (P<0.05). Serum levels of IL-17

NF-κ B

IL-6

and IL-9 in observation group were significantly lower

while IL-27 was higher than those in control group after treatment (P<0.01). Conclusion: On this basis of conventional western medicine

modified Shenfu Yangrong Tang plays a good therapeutic effect and is safe in treating chronic stage of VMC

and its mechanism may be associated with regulating serum levels of IL-17

IL-27

NF-κ B

IL-6

and IL-9.

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