Objective: To investigate the efficacy of Yunpi Zhushi decoction in treating hypertension patients with spleen damp-heat type metabolic syndrome (MS)

and observe its effect on serum levels of adiponectin (ADP)

high-sensitive-C-reactive protein(hs-CRP)

homocysteine(Hcy)

endothelin (ET)

and vascular von willebrand factor(vWF). Method: One hundred and eighteen patients with MS hypertension were randomly divided into control group and treatment group (59 cases in each group). The patients in control group orally took Telmisartan tablets (40 mg/time and 1 time/day). Based on the treatment in control group

the patients in treatment group were given with Yunpi Zhushi decoction

1 dose/day

twice daily in night and morning. All patients were continuously treated for 3 months. Then indexes of blood pressure variability

physique study

blood fat

and blood glucose were compared between two groups. And the serum levels of ADP

hs-CRP

HCY

ET

and vWF were detected in both groups. Result: After treatment

24 h diastolic pressure standard deviation (24 hDSD)

diastolic pressure standard deviation at night (nDSD)

systolic pressure standard deviation at daytime (dSSD)

and diastolic pressure standard deviation at daytime (dDSD) were obviously decreased in both groups (P<0.01)

but there was no statistically significant difference between two groups. After treatment

indexes of physique study

blood fat

and blood glucose were obviously decreased in treatment group

and lower than those of control group (P<0.01). Serum level of ADP in treatment group was remarkably higher

while hs-CRP

HCY

ET

and vWF were lower than those in control group with statistically significant differences (P<0.01). Conclusion: Based on western medicine

Yunpi Zhushi decoction has obvious efficacy in treating hypertension patients with spleen damp-heat type metabolic syndrome

and can up-regulate serum level of ADP and down-regulate serum levels of hs-CRP

Hcy

ET

and vWF.