Stroke is one of the major causes of global death and disability; and ischemic stroke is the most common type of stroke. In recent years

with the development of regenerative medicine

stem cell therapy has become a hotspot. Studies have confirmed that stem cell therapy

including activation of endogenous neural stem cells and exogenous stem cell transplantation

can promote endogenous nerve and vascular regeneration

repair nerve damage

so as to improve neurological function

with a broad prospect in the treatment of ischemic stroke. However

survival

migration and differentiation rates of stem cells remain low

with no effective solution. Traditional Chinese medicine(TCM) have been applied in the treatment of stroke for thousands of years. Recently

researchers have found that TCM can promote proliferation

differentiation and other physiological activities of stem cells in vitro and in vivo. TCM combined with stem cell therapy has been used to treat multiple diseases. Further studies have found that TCM can activate endogenous neural stem cells of ischemic brain tissues

and promote nerve repair

with a synergistic effect on transplanted stem cells. To provide theoretical support for subsequent studies

we summarized the studies of ischemic stroke in recent years and reviewed the progress of studies on the effect of TCM with stem cell therapy in treating ischemic stroke.