Objective: In this paper

taking Berberis amurensis root and Fomes fomentarius fruitbody as raw materials

based on the theory of compatibility of traditional Chinese medicine

the preparation method was used to develope Xiaobo Muti oral ulcer film. Method: Orthogonal test was adopted to optimize the formula of Xiaobo Muti oral ulcer film with comprehensive score of moldability

appearance

softness and toughness as index.Efficacy of the film was investigated by the establishment of rat oral ulcer animal model

female rats were randomly divided into blank group

model group

positive control group

high

medium and low dose group of Xiaobo Muti oral ulcer film.The positive control group was administered with propolis oral cavity membrane

one tablet each time

two times a day.The high dose group of Xiaobo Muti oral ulcer film was given 4 times within one day

4 tablets each time.The medium dose group of Xiaobo Muti oral ulcer film was administered 2 times a day

2 tablets each time.The low dose group of Xiaobo Muti oral ulcer film was administered once a day

one tablet each time.These all were given for a period of 7 days. Result: The best formula of Xiaobo Muti oral ulcer film was B. amurensis root extract-F. fomentarius fruitbody extract-starch-sodium carboxymethyl cellulose-glycerin-refining honey-water (8:4:10:2:3:20:500)

under this formula

the score of each index was as follows:23.6 points of moldability

23.8 points of appearance

22.5 points of softness

23.3 points of toughness. Conclusion: Xiaobo Muti oral ulcer film has antibacterial and anti-inflammatory

it can promote healing effect for treatment of oral ulcer significantly.B. amurensis root and F. fomentarius fruitbody can work together to compose prescription

which can enhance the effect of treatment of oral ulcer caused by the fire in the spleen

stomach and liver.