Objective: To investigate the chemical constituents of Scutellaria galericulata. Method: The herb of S.galericulata was crushed and then extracted with 95% ethanol.The extracts were combined and concentrated under reduced pressure.The extracts were dispersed in water and respectively extracted with petroleum ether

ethyl acetate

chloroform and n-butanol to get petroleum ether fraction

ethyl acetate fraction

chloroform fraction and n-butanolfraction.Ethyl acetate fraction were separated and purified by silica gel column chromatography

Sephadex LH-20 and HPTLC.The structures of the glycosides compounds were identified by their physico-chemical properties and spectral data. Result: Eleven compounds were isolated and purified as:isocrenatoside (1)

osmanthuside B6 (2)

eutigoide A (3)

plantainoside C (4)

calceorioside B (5)

isomartynoside (6)

verbascoside (7)

acteoside (8)

desrhamnosyl acteoside (9)

5

7-dihydroxy-8

2'-dimethoxyflavone-7-O-β-D-glucopyranoside (10)

and apigenin-7-O-rhamnoside (11). Conclusion: Compounds 1-4 and 7-11 were isolated from S.galericulata for the first time

and the literature review showed that plantainoside C

apigenin-7-O-rhamnoside and other compounds had anti-inflammatory and antioxidant activities

providing a good reference for further studies onpharmacodynamic material basis and the development and utilization of S.galericulata.