Objective: To explore the relationship between long-term stability and accelerated stability of certified reference materials (CRMs) of natural products

in order to provide technical support for the prediction of validity of CRMs. Method: In the process of development of 5 CRMs(cinnamaldehyde

sakuranetin

pedunculoside

stachyose and β-sitosterol)

the long-term stability test was carried out by determining their purities at 0

1

2

3

6

9

12

18

24 months under the temperature of 0-8℃ and the accelerated stability test was carried out by determining their purities at 0

1

2

3

6 months under temperature of (40±2)℃ and relative humidity of (75±5)%. Result: The results of statistical analysis showed that both long-term stability and accelerated stability were excellent and there were no significant difference between long-term stability and accelerated stability. Conclusion: The validity of 24 months of CRMs can be predicted on the bases of the result of accelerated stability test in 6 months.