Objective: To observe the effect of Qibai granules on antioxidation and sex hormone levels for the patients with female chloasma Qi stagnation and blood stasis syndrome. Method: The 126 cases of patients with female chloasma Qi stagnation and blood stasis syndrome were divided into observation group (66 cases) and control group (60 cases).Patients in observation group were treated by Qibai granules

while patients in control group were treated by hydroquinone cream.The clinical effects were observed and compared between two groups. Result: The scores of skin lesions for observation group were lower than those in control group at week 8(P<0.05).The total effective rate and total satisfaction for observation group were higher than those in control group (P<0.05).The levels of superoxide dismutase (SOD)

cata-lase (CAT) for observation group were higher than those in control group (P<0.05).The levels of malondialdehyde (MDA)

E2

follicle-stimulating hormone (FSH)

luteinizing hormone (LH) for observation group were lower than those in control group (P<0.05).There was no significant difference in safety classification between two groups.The scores of WHO Quality of Life Measure-Abbreviated version (WHOQOL-BREF) for observation group were higher than those in control group after treatment (P<0.05).There was no significant difference on the adverse reactions

and both groups showed no obvious abnormalities in results of blood routine

urine routine

stool routine

liver and kidney function tests. Conclusion: Qibai granules had good clinical effects for patients with female chloasma Qi stagnation and blood stasis syndrome; it can improve the skin lesions

the levels of sex hormone and quality of life

with obvious antioxidant effect

high safety

without obvious adverse reactions or significant effects on blood routine

urine routine

stool routine

liver and kidney function results

so it can be used as an optimal treatment plan.