射干麻黄汤治疗儿童哮喘发作期临床疗效及对血清细胞因子、骨桥蛋白及TIMP-1水平的影响

李弯; 梁敏; 边俊梅; 熊诗思

doi:10.13422/j.cnki.syfjx.2017200180

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射干麻黄汤治疗儿童哮喘发作期临床疗效及对血清细胞因子、骨桥蛋白及TIMP-1水平的影响

临床 | 更新时间：2024-01-04

- 射干麻黄汤治疗儿童哮喘发作期临床疗效及对血清细胞因子、骨桥蛋白及TIMP-1水平的影响
- Clinical Efficacy of Shegan Mahuangtang and Effect on Serum Cytokines, OPN and TIMP-1 in Acute Asthmatic Childhood
- 中国实验方剂学杂志 2017年23卷第20期页码：180-184
- 作者机构：
- 作者简介：
- 基金信息：
  
  武汉市卫生和计划生育委员会临床医学科研项目（WX14C17）
- DOI：10.13422/j.cnki.syfjx.2017200180
  中图分类号： R272
- 纸质出版日期：2017
- 稿件说明：
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李弯, 梁敏, 边俊梅, 等. 射干麻黄汤治疗儿童哮喘发作期临床疗效及对血清细胞因子、骨桥蛋白及TIMP-1水平的影响[J]. 中国实验方剂学杂志, 2017,23(20):180-184.

LI Wan, LIANG Min, BIAN Jun-mei, et al. Clinical Efficacy of Shegan Mahuangtang and Effect on Serum Cytokines, OPN and TIMP-1 in Acute Asthmatic Childhood[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(20): 180-184.
李弯, 梁敏, 边俊梅, 等. 射干麻黄汤治疗儿童哮喘发作期临床疗效及对血清细胞因子、骨桥蛋白及TIMP-1水平的影响[J]. 中国实验方剂学杂志, 2017,23(20):180-184. DOI： 10.13422/j.cnki.syfjx.2017200180.

LI Wan, LIANG Min, BIAN Jun-mei, et al. Clinical Efficacy of Shegan Mahuangtang and Effect on Serum Cytokines, OPN and TIMP-1 in Acute Asthmatic Childhood[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(20): 180-184. DOI： 10.13422/j.cnki.syfjx.2017200180.

摘要

目的：探讨射干麻黄汤治疗儿童哮喘发作期临床疗效及对血清白细胞介素-6（interleukin-6，IL-6），白细胞介素-8（interleukin-8，IL-8），肿瘤坏死因子-α（tumor necrosis factor-α，TNF-α）和超敏C反应蛋白（high sensitive-C reaction protein，hs-CRP），骨桥蛋白（osteopontin，OPN）及基质金属蛋白酶的组织抑制剂-1（tissue inhibitor of metalloproteinases-1，TIMP-1）水平的影响。方法：选取哮喘急性发作期患儿161例，随机分为治疗组（81例），对照组（80例）。对照组采用西医常规疗法，治疗组予射干麻黄汤进行治疗，清水煎煮，每日1剂，治疗后对哮喘患儿临床疗效，血清IL-6，IL-8，TNF-α，hs-CRP，OPN及TIMP-1水平进行比较，并观察两组患儿不良反应。结果：治疗组患者总有效率为93.83%，对照组为81.25%，治疗组优于对照组（P<0.05）；与治疗前比较，治疗后两组患儿血清IL-6，IL-8，TNF-α，hs-CRP水平均明显降低（P<0.05），且治疗组血清IL-6，IL-8，TNF-α，hs-CRP水平明显低于对照组（P<0.05）；与治疗前比较，治疗后两组患儿OPN与TIMP-1水平均有明显降低（P<0.05）；治疗组OPN与TIMP-1表达明显低于对照组（P<0.05）；与治疗前比较，治疗后两组中医证候积分均有明显改善（P<0.05）；治疗组中医证候积分低于对照组（P<0.05）；两组不良反应比较差异无统计学意义。结论：射干麻黄汤治疗哮喘发作期患儿临床疗效显著，作用机制可能与减少患者细胞因子IL-6，IL-8，TNF-α和hs-CRP水平，降低OPN与TIMP-1表达有关。

Abstract

Objective: To investigate the clinical efficacy of Shegan Mahuangtang and its effect on interleukin-6 (IL-6)

interleukin-8 (IL-8)

tumor necrosis factor-α (TNF-α)

high sensitive-C reaction protein (hs-CRP)

osteopontin (OPN) and tissue inhibitors of matrix metalloproteinases-1 (TIMP-1) in acute asthmatic childhood. Method: The 161 children in acute exacerbation of bronchial asthma treated in our hospital from November 2014 to April 2016 were selected and randomly divided into two groups according to the admitted order

with 81 cases in treatment group and 80 cases in control group.Patients in control group were treated with the routine western medicine therapy

while patients in treatment group were treated with Shegan Mahuangtang which was decocted by clear water

one dose per day.Then their clinical efficacy and effects on serum cytokines

OPN and TIMP-1 in acute asthmatic childhood were compared between two groups; in addition

adverse reactions were observed in two groups. Result: The total effective rate was 93.83% in treatment group

higher than 81.25% in control group (P<0.05).The levels of IL-6

IL-8

TNF-α and hs-CRP in serum were decreased after treatment in both groups (P<0.05)

and the above levels in treatment were lower than those in control group after treatment (P<0.05).The expression levels of OPN and TIMP-1 were also decreased in both groups after treatment (P<0.05)

and the levels in treatment group were lower than those in control group (P<0.05).Traditional Chinese medicine (TCM) syndrome scores were significantly improved in both groups (P<0.05)

and the TCM syndrome scores in treatment group were lower than those in control group after treatment (P<0.05).In addition

there was no statistically significant difference in adverse reactions between two groups. Conclusion: Shegan Mahuangtang is very effective in treating children in acute exacerbation of bronchial asthma.It can significantly lower the value of serum cytokines

OPN and TIMP-1

improve the TCM syndrome score

and the mechanism may be related to decreasing the levels of cytokines and reducing the expression levels of OPN and TIMP-1.

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