Objective: Data mining method was adopted to summarize the medication regularity in each phase and the action mechanism of infertility with traditional Chinese medicine(TCM) periodic therapy. Method: Clinical research literatures of treatment for infertility by TCM periodic therapy in 1980-2016 were searched

a database of Excel was established and SPSS Clementine 12.0 software was used to analyze the data. Result: A total of 143 TCMs and 3 609 frequencies were involved in the 85 literatures.Sumed up the TCMs with high usage frequency in the prescriptions for each phase.The result preliminary proved that tonifying the kidney was used throughout the TCM periodic therapy. Conclusion: The main rules of treatment in post menstrual period are nourishing the essence and enriching the blood

in ovulation are promoting blood circulation for removing blood stasis and regulating blood vessels

in premenstrual phase are warming kidney and activating Yang

in menstrual period are promoting blood circulation and removing blood stasis for promoting tissue regeneration.The key point of TCM periodic therapy for infertility is regulating Tiangui in the kidney.