参苓白术散对老年社区获得性肺炎肺脾气虚证患者血清炎症因子及免疫功能的影响

孙志欣; 陈莉; 李锐; 张莹

doi:10.13422/j.cnki.syfjx.2017210161

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参苓白术散对老年社区获得性肺炎肺脾气虚证患者血清炎症因子及免疫功能的影响

临床 | 更新时间：2024-01-04

- 参苓白术散对老年社区获得性肺炎肺脾气虚证患者血清炎症因子及免疫功能的影响
- Effect of Shenling Baishu San Combined with Antibiotics on Serum Inflammatory Factors, Immune Function in Senile Community-acquired Pneumonia with Syndrome of Qi Deficiency of Both Lung and Spleen
- 中国实验方剂学杂志 2017年23卷第21期页码：161-165
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家自然科学基金项目（81303021）;天津市高等学校科技发展基金计划项目（20110223）
- DOI：10.13422/j.cnki.syfjx.2017210161
  中图分类号： R259
- 纸质出版日期：2017
- 稿件说明：
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孙志欣, 陈莉, 李锐, 等. 参苓白术散对老年社区获得性肺炎肺脾气虚证患者血清炎症因子及免疫功能的影响[J]. 中国实验方剂学杂志, 2017,23(21):161-165.

SUN Zhi-xin, CHEN Li, LI Rui, et al. Effect of Shenling Baishu San Combined with Antibiotics on Serum Inflammatory Factors, Immune Function in Senile Community-acquired Pneumonia with Syndrome of Qi Deficiency of Both Lung and Spleen[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(21): 161-165.
孙志欣, 陈莉, 李锐, 等. 参苓白术散对老年社区获得性肺炎肺脾气虚证患者血清炎症因子及免疫功能的影响[J]. 中国实验方剂学杂志, 2017,23(21):161-165. DOI： 10.13422/j.cnki.syfjx.2017210161.

SUN Zhi-xin, CHEN Li, LI Rui, et al. Effect of Shenling Baishu San Combined with Antibiotics on Serum Inflammatory Factors, Immune Function in Senile Community-acquired Pneumonia with Syndrome of Qi Deficiency of Both Lung and Spleen[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(21): 161-165. DOI： 10.13422/j.cnki.syfjx.2017210161.

摘要

目的：探讨参苓白术散加减联合抗生素对老年社区获得性肺炎（community-acquired pneumonia，CAP）肺脾气虚证患者临床疗效、血清炎症因子及免疫功能的影响。方法：选取天津中医药大学第一附属医院2014年1月到2016年1月符合入选标准的老年CAP肺脾气虚证患者236例，按照随机数字表法分为对照组（118例）和治疗组（118例），对照组给予抗生素治疗，治疗组在对照组的基础上给予参苓白术散加减治疗，两组患者连续治疗10 d，观察并比较两组患者临床疗效、血清炎症介质、体液免疫指标和T淋巴细胞亚群水平变化情况。结果：治疗组临床总有效率和细菌清除率均高于对照组（P < 0.05）；治疗组患者临床症状恢复时间低于对照组（P < 0.05）；治疗后，治疗组患者血清白细胞介素-6（interleukin-6，IL-6），肿瘤坏死因子-α（tumor necrosis factor-alpha，TNF-α），降钙素原（procalcitonin，PCT），C反应蛋白（C-reactive protein，CRP）水平降低，且明显低于对照组（P < 0.05）；治疗组治疗后血清免疫球蛋白A（immunoglobulin A，IgA），免疫球蛋白M（immunoglobulin M，IgM），CD4+和CD4+/CD8+水平上升，且治疗组高于对照组（P < 0.05）；两组患者治疗后CD8+水平下降，且治疗组低于对照组（P < 0.05）。结论：参苓白术散加减联合抗生素治疗老年CAP肺脾气虚证患者的临床效果显著，对于抑制机体炎症反应和增强机体免疫功能具有重要作用。

Abstract

Objective: To explore the effect of Shenling Baishu San combined with antibiotics on inflammatory factors

immune function and clinical efficacy in senile community-acquired pneumonia with syndrome of Qi deficiency of both lung and spleen. Method: From January 2014 to January 2016

236 CAP patients were included. They were randomly divided into control group (118 cases) and treatment group (118 cases) by random number table. Treatment group and control group were respectively treated with Shenling Baishu San plus moxifloxacin and moxifloxacin for 10 days. The clinical curative effect and the changes of inflammatory mediators and immunity levels in two groups were observed. Result: The total effective rate and the bacterial clearance rate of treatment group were both higher than those of control group (P < 0.05)

and the clinical recovery time of treatment group was lower than that of control group (P < 0.05). After treatment

levels of serum interleukin-6 (IL-6)

tumor necrosis factor-alpha (TNF-α)

procalcitonin (PCT) and C-reactive protein (CRP) in treatment group were lower than those in control group (P < 0.05). After treatment

serum immunoglobulin A (IgA)

immunoglobulin M (IgM)

CD4+ and CD4+/CD8+ levels were increased in treatment group

which were significantly higher than those in control group (P < 0.05); CD8+ level was decreased in both groups

and the level in treatment group was significantly lower than that of control group (P < 0.05). Conclusion: Shenling Baishu San combined with antibiotics has a remarkable effect in the treatment of senile community-acquired pneumonia with syndrome of Qi deficiency of both lung and spleen

with an important role in inhibiting the body's inflammatory response and enhancing the immune function.

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