Flavonoids have a variety of pharmacological activities

including anti-inflammatory

anti-oxidation

anti-thrombosis

antibacterial

antiviral

and hypolipidemic

etc. As a commonly used safe edible fungi

Aspergillus niger is widely used in microbial transformation and plays an important role in the biotransformation of flavonoids. This paper reviews the progress of biotransformation of flavonoids and their derivatives in A. niger at home and abroad in recent 15 years in order to provide reference for the further development and application of A. niger. The results showed that the main types of flavonoids participated in biotransformation were flavone

flavonoid glycoside

flavanone

chalcone

polymethoxyflavonoids

and isoflavanone. Hydroxylation

dehydroxylation

methylation

demethylation

carbonylation

decarbonylation

glycosylation

and de-glycosylation were the main reactions. The transformation mechanism may be generated with enzyme involved

and would develop conversion products after the occurrence of the above reaction. The study on the progress of the transformation of flavonoids from A. niger was carried out not only to provide theoretical guidance for the application of A. niger to the actual production of flavonoids

but also lay the theoretical basis and reference for the microbial efficient transformation of chemical compositions with pharmacological activity.