Objective: To synthesize bezohpenone derivatives

characterize their structures and study their antifungal activities. Method: Benzophenone derivatives were synthesized by Friedel-Crafts acylation reaction with benzoyl chloride or phthalic annhydride as the raw materials. The structures of these compounds were elucidated by 1H-NMR

13C-NMR and MS-ESI. Their effects on minimum inhibitory concentration (MIC) of four fungi were investigated with antimicrobial susceptibility test. Result: The results showed that 13 benzophenone derivatives had antifungal activity in varying degrees

and the carbonyl group was a key to the antifungal activity of benzophenone derivatives. Different substituent groups had significant differences in the effect on their antifungal activities and the diphenyl ketone derivatives with multiple chlorine atoms showed the most excellent antifungal activity. Conclusion: 13 benzophenone derivatives had antifungal activity. The results of this experiment offered a method and reference for structure modification of natural benzophenone compounds with antifungal activity.