5种常用药用辅料对党参颗粒吸湿性及成型性的影响

高建德; 朱晓玉; 宋开蓉; 刘雄; 乔婧; 师婷婷

doi:10.13422/j.cnki.syfjx.2017230013

您当前的位置：

首页 >

文章列表页 >

5种常用药用辅料对党参颗粒吸湿性及成型性的影响

药剂与炮制 | 更新时间：2024-01-04

- 5种常用药用辅料对党参颗粒吸湿性及成型性的影响
- Effect of Five Kinds of Pharmaceutical Excipients on Moisture Absorption and Formability of Codonopsis Radix Granules
- 中国实验方剂学杂志 2017年23卷第23期页码：13-17
- 作者机构：
- 作者简介：
- 基金信息：
  
  兰州市科技局项目（2014-1-17）;甘肃省科技攻关项目（GYC13-05）;甘肃省中医方药挖掘与创新转化重点实验室开放基金项目（ZYFYZH-KJ-2015-002）
- DOI：10.13422/j.cnki.syfjx.2017230013
  中图分类号： R283.6
- 纸质出版日期：2017
- 稿件说明：
移动端阅览
高建德, 朱晓玉, 宋开蓉, 等. 5种常用药用辅料对党参颗粒吸湿性及成型性的影响[J]. 中国实验方剂学杂志, 2017,23(23):13-17.

GAO Jian-de, ZHU Xiao-yu, SONG Kai-rong, et al. Effect of Five Kinds of Pharmaceutical Excipients on Moisture Absorption and Formability of Codonopsis Radix Granules[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(23): 13-17.
高建德, 朱晓玉, 宋开蓉, 等. 5种常用药用辅料对党参颗粒吸湿性及成型性的影响[J]. 中国实验方剂学杂志, 2017,23(23):13-17. DOI： 10.13422/j.cnki.syfjx.2017230013.

GAO Jian-de, ZHU Xiao-yu, SONG Kai-rong, et al. Effect of Five Kinds of Pharmaceutical Excipients on Moisture Absorption and Formability of Codonopsis Radix Granules[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(23): 13-17. DOI： 10.13422/j.cnki.syfjx.2017230013.

摘要

目的：研究5种常用药用辅料微晶纤维素（MCC），糊精（DE），羧甲基淀粉钠（CMS-Na），可溶性淀粉（ST）和麦芽糊精（MA）对党参颗粒吸湿及其成型性的影响。方法：以单一辅料，2种辅料不同配比混合后分别与党参浸膏按1∶1混合制粒，通过Higuch方程，Weibull分布和一元二次曲线方程模型拟合党参颗粒的吸湿动力学，并结合成型性和溶化性，筛选制备党参颗粒的最佳处方。结果：综合吸湿性和成型性，以党参浸膏-MCC-DE（3∶2∶1）组合时，党参颗粒均可在2 min内全溶，成型率85.41%，48 h内平衡吸湿量6.28%。结论：按最优处方所制党参颗粒的阻湿性和成型性均较好，工艺稳定可行，能有效降低党参颗粒的吸湿性。

Abstract

Objective: To study on the effect of several medicinal excipients

such as microcrystalline cellulose (MCC)

soluble starch (ST)

dextrin (DE)

maltodextrin (MA) and sodium carboxymethyl starch (CMS-Na)

on the moisture absorption and formability of Codonopsis Radix granules. Method: A single excipient or two kinds of excipients with different ratio were mixed with Codonopsis Radix extract by 1:1

the moisture absorption kinetics of Codonopsis Radix granules was fitted by Higuch equation

Weibull distribution and unitary quadratic curve equation model

respectively.The best prescription of this granules was evaluated by the moisture absorption

forming and dissolubility. Result: Optimum molding materials was mixture of MCC and DE

ratio of Codonopsis Radix extract-MCC-DE was 3:2:1

Codonopsis Radix granules could be totally dissolved in 2 min with forming rate of 85.41%

equilibrium moisture content of this granules within 48 h was 6.28%. Conclusion: The optimum process is stable and feasible

it can effectively reduce the hygroscopicity of Codonopsis Radix granules.

关键词

Keywords

references

浏览量

下载量

CSCD

文章被引用时，请邮件提醒。

提交

工具集

关联资源

赤石脂的本草考证、品质评价及物相分析

中药泡腾片常见问题及粉体改性解决策略的前景分析

黄芪多糖颗粒防潮辅料的研究

壳聚糖絮凝澄清工艺与醇沉工艺纯化乙肝宁复方水提液的对比