参桂益心汤对慢性心力衰竭患者外周血单核细胞Toll样受体4/核转录因子-B信号通路的影响

冯庆涛; 杨静; 张燕; 吕尚增; 苗华为

doi:10.13422/j.cnki.syfjx.2017230146

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参桂益心汤对慢性心力衰竭患者外周血单核细胞Toll样受体4/核转录因子-B信号通路的影响

临床 | 更新时间：2024-01-04

- 参桂益心汤对慢性心力衰竭患者外周血单核细胞Toll样受体4/核转录因子-B信号通路的影响
- Effect of Shengui Yixin Decoction on Toll-like Receptors 4/Nuclear Factor Kappa B in Patients with Chronic Heart Failure
- 中国实验方剂学杂志 2017年23卷第23期页码：146-151
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家自然科学基金项目（81573698）;河北省中医药管理局科研计划项目（2014025）
- DOI：10.13422/j.cnki.syfjx.2017230146
  中图分类号： R285.6
- 纸质出版日期：2017
- 稿件说明：
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冯庆涛, 杨静, 张燕, 等. 参桂益心汤对慢性心力衰竭患者外周血单核细胞Toll样受体4/核转录因子-B信号通路的影响[J]. 中国实验方剂学杂志, 2017,23(23):146-151.

FENG Qin-tao, YANG Jing, ZHANG Yan, et al. Effect of Shengui Yixin Decoction on Toll-like Receptors 4/Nuclear Factor Kappa B in Patients with Chronic Heart Failure[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(23): 146-151.
冯庆涛, 杨静, 张燕, 等. 参桂益心汤对慢性心力衰竭患者外周血单核细胞Toll样受体4/核转录因子-B信号通路的影响[J]. 中国实验方剂学杂志, 2017,23(23):146-151. DOI： 10.13422/j.cnki.syfjx.2017230146.

FENG Qin-tao, YANG Jing, ZHANG Yan, et al. Effect of Shengui Yixin Decoction on Toll-like Receptors 4/Nuclear Factor Kappa B in Patients with Chronic Heart Failure[J]. Chinese journal of experimental traditional medical formulae, 2017, 23(23): 146-151. DOI： 10.13422/j.cnki.syfjx.2017230146.

摘要

目的：观察参桂益心汤对慢性心力衰竭患者外周血单核细胞Toll样受体4/核转录因子-κB（TLR4/NF-κB）信号通路的影响。方法：124例慢性心力衰竭患者按随机数字表法分为对照组（50例）和治疗组（74例），对照组给予西医常规药物治疗，治疗组在对照组基础上加用参桂益心汤，每日1剂，疗程4周。比较两组治疗前后心功能，包括心率（HR），左室射血分数（LVEF），左室舒张末期内径（LVDD），6 min步行实验距离（6 mWT）；测定两组治疗前后外周血单核细胞TLR4，NF-κB及肿瘤坏死因子-α（TNF-α），白细胞介素-6（IL-6），白细胞介素-1β（IL-1β）mRNA和蛋白表达；患者出院后随访6~18个月，观察两组再住院率、病死率及再住院次数。结果：与对照组比较，治疗组总有效率明显升高（P<0.05）；与对照组比较，治疗组HR，LVDD明显降低，LVEF，6 mWT明显增加（P<0.05）；治疗组较对照组TLR4，NF-κB，TNF-α，IL-6，IL-1β mRNA和蛋白表达明显降低（P<0.05）；二组患者均较治疗前好转（P<0.05）。治疗组再住院率、病死率及再住院次数较对照组明显降低（P<0.05）。结论：参桂益心汤能够抑制慢性心力衰竭患者外周血单核细胞TLR4/NF-κB信号通路，抑制炎症，改善患者心功能。

Abstract

Objective: To observe the effect of Shengui Yixin decoction on plasma monocyte Toll-like receptors 4/nuclear factor kappa B (TLR4/NF-κB) signal pathway in patients with chronic heart failure. Method: A total of 124 patients with chronic heart failure were divided into control group (50 cases) and treatment group (74 cases) by random number table. The control group was given routine western medicine therapy. The treatment group was given Shengui Yixin decoction for 4 weeks

1 agent/day in addition to the therapy of control group. Heart rate (HR)

left ventricular ejection fraction (LVEF)

left ventricular end diastolic diameter (LVDD)

and 6 minute walking distance (6 mWT)

TLR4

NF-κB

tumor necrosis factor-α (TNF-α)

interleukin-6 (IL-6)

interleukin1β (IL-1β) mRNA and protein expressions in two groups before and after treatment were observed. Patients were followed up for 6 to 18 months after discharge. Rate of rehospitalization

fatality and the number of rehospitalization were compared between two groups. Result: Compared with control group

the total efficiency of treatment group increased significantly (P<0.05). After the treatment

LVDD

TLR4

NF-κB

TNF-α

IL-6 and IL-1β mRNA and protein expressions of treatment group were significantly lower than those of control group; LVEF

6 mWT of treatment group were significantly higher than those of control group (P<0.05). both groups showed alleviations compared with before hospitalization (P<0.05). Rehospitalization rate

death rate and frequency of rehospitalization of treatment group were lower than those of control group (P<0.05). Conclusion: Shengui Yixin decoction in treating patients with chronic heart failure can significantly inhibit TLR4/NF-κB signal pathway and inflammation and improve the patients' cardiac function.

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