Objective: To investigate the effects of Shuangshen Xionglian (SSXL) granule on atherosclerotic inflammation in ApoE-/- mice with high-fat diet. Method: C57BL/6 mice were used as normal control group (BLA). ApoE-/- mice were randomly divided into 4 groups:model group with atherosclerosis (MOD)

probucol treatment group (PRO

216 mg·kg-1)

SSXL high dose group (SSXL-H

1.6 g·kg-1) and SSXL low dose group (SSXL-L

0.8 g·kg-1). After 2 weeks of high-fat diet

blood lipids were measured by biochemical method and ApoE-/- mice were treated with different drugs. Blood lipids were measured again after 8-week treatment. Aortic intima thicknesses in ApoE-/- mice were analyzed by ultrasonic methods. Aortic plaque areas were observed by oil red O staining and ratio of plaque area/intravascular area was calculated. The expression levels of tumor necrosis factor (TNF)-α

interleukin (IL)-1α

IL-10 and monocyte chemoattractant protein (MCP)-1 in serum were detected by flow type high throughput multi-factor detection technique. Result: SSXL granule could decrease aortic intima thicknesses in ApoE-/- mice

reduce ratio of plaque area/intravascular area

inhibit the expression of TNF-α and MCP-1

but with no significant effects on changes of blood lipids. Conclusion: SSXL granule had obvious anti-atherosclerotic effect by suppressing inflammation but not depending on blood lipids level.