Objective: To observe the effect of Wuwei Xiaoke decoction in treatment of type 2 diabetes with Qi and Yin deficiency. Method: A total of 128 patients with type 2 diabetes were selected and randomly divided into two groups:treatment group (64 cases) and control group (64 cases). Two groups were both treated with the basic therapy; the treatment group was additionally given Wuwei Xiaoke decoction

and control group was additionally given placebo. Clinical symptoms

sign changes

fasting blood glucose (FBG)

postprandial 2 h blood sugar (P2 hBG)

glycosylated hemoglobin (HbA1c)

fasting insulin level (FINS)

insulin resistance index (HOMA-IR)

traditional Chinese medicine (TCM) syndrome score of two groups were observed after treatment. Result: Two groups were evenly distributed

with a good baseline status and strong comparability. In the aspect of TCM syndrome scores

treatment group was significantly better than control group in the alleviation of clinical symptoms (P<0.05). The total clinical effective rate was 93.55% in treatment group was significantly higher than control group (P<0.05). After treatment

two groups showed alleviations in FBG and P2 hBG

HbA1c

FINS and HOMA-IR

particularly the treatment (P<0.05). Conclusion: Wuwei Xiaoke decoction has a significant efficacy and safety in treating type 2 diabetes with Qi and Yin deficiency syndrome

and thus is worth clinical popularization.