Syndrome of blood stasis with Qi stagnation is a common clinical syndrome and the formation is closely related to the diet

mood

environment and other factors. With the quickening pace of modern life and the increasing pressures of life

emotional discomfort is inevitable. In addition

greasy diet and other factors are easy to cause Qi stagnation and blood stasis diseases. Clinical research and treatment most stay in the external macro-means and technology

so it is difficult to understand systematically and deeply about the microcosmic changes of syndrome development and the rule of syndrome evolution. This needs to establish animal models that are related to the clinical pathogenesis. In order to understand the research status about animal models of Qi stagnation and blood stasis syndrome and disease-syndrome combination

the modeling methods

model validation and principles were reviewed in this paper. The common modeling methods of Qi stagnation and blood stasis syndrome include adrenaline method

dextran method

acousto-optic complex stimulation

binding method

clipping tail method

high fat plus cold coagulation

sleep deprivation and so on. The hemorheology indexes are the leading indicator of model validation

followed by open field test

and microcirculation

weight

neurotransmitter

vascular endothelial factor and other tests. The common disease-syndrome combination models of Qi stagnation and blood stasis syndrome include the models of Qi stagnation and blood stasis syndrome with endometriosis

Qi stagnation and blood stasis syndrome with gynecological disease characteristics

Qi stagnation and blood stasis syndrome with diabetes

Qi stagnation and blood stasis syndrome with non-small cell lung cancer

and Qi stagnation and blood stasis syndrome with chronic non-bacterial prostatitis. Different modeling methods are used in the different applications. We summarized the modeling methods

principles and testing indicators in recent years to standardize the animal model of Qi stagnation blood stasis syndrome.