To provide a general top-level structure to the domain ontology experts by introducing basic formal ontology (BFO)

which facilitated the interoperability of terminology created by experts in various fields. On the basis of brief introduction of BFO and other top-level ontologies

this paper briefly summarized the domain ontologies based on BFO

and took top ontology of bioscience (BioTop) and ontology for general medical science(OGMS) as examples. There were 227 domain-based ontologies based on BFO

25 of which were related to the disease. BFO has been widely used in the field of biomedical field.The introduction of BFO in the construction of domain ontology not only can improve the quality of data

reduce the redundant work

but also provide the framework and foundation for the construction of domain ontology

which can provide the possibility for future interaction and sharing in knowledge.