天宁饮类方对不同证型偏头痛血液流变学的影响

全亚萍; 王华; 朱银杏; 许军林; 陈艳; 王玮

doi:10.13422/j.cnki.syfjx.2018030173

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天宁饮类方对不同证型偏头痛血液流变学的影响

临床 | 更新时间：2024-01-04

- 天宁饮类方对不同证型偏头痛血液流变学的影响
- Effect of Tianning Drink Associated Prescriptions on Hemorheology Level in Patients of Migraine with Different Syndrome Types
- 中国实验方剂学杂志 2018年24卷第3期页码：173-179
- 作者机构：
- 作者简介：
- 基金信息：
  
  江苏省“六大人才高峰”C类项目（2014-WSN-074）;泰州市科技支撑计划项目（TS013）
- DOI：10.13422/j.cnki.syfjx.2018030173
  中图分类号： R277.7
- 纸质出版日期：2018
- 稿件说明：
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全亚萍, 王华, 朱银杏, 等. 天宁饮类方对不同证型偏头痛血液流变学的影响[J]. 中国实验方剂学杂志, 2018,24(3):173-179.

QUAN Ya-ping, WANG Hua, ZHU Yin-xing, et al. Effect of Tianning Drink Associated Prescriptions on Hemorheology Level in Patients of Migraine with Different Syndrome Types[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(3): 173-179.
全亚萍, 王华, 朱银杏, 等. 天宁饮类方对不同证型偏头痛血液流变学的影响[J]. 中国实验方剂学杂志, 2018,24(3):173-179. DOI： 10.13422/j.cnki.syfjx.2018030173.

QUAN Ya-ping, WANG Hua, ZHU Yin-xing, et al. Effect of Tianning Drink Associated Prescriptions on Hemorheology Level in Patients of Migraine with Different Syndrome Types[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(3): 173-179. DOI： 10.13422/j.cnki.syfjx.2018030173.

摘要

目的：通过观察天宁饮类方对不同证型偏头痛患者头痛症状及血液流变学指标的影响，了解天宁饮类方治疗偏头痛的疗效及作用机制。方法：将216例偏头痛患者采取随机数字表法分成治疗组、对照组，各108例，研究过程中剔除1例，脱落15例。最终有效病例200例，两组各100例。其中风痰瘀阻证治疗组22例，对照组20例，风痰瘀阻兼肝阳上亢证治疗组44例，对照组48例，风痰瘀阻兼气血亏虚证治疗组19例，对照组17例，风痰瘀阻兼肝肾阴虚证两组各15例。风痰瘀阻证治疗组口服天宁饮，风痰瘀阻兼肝阳上亢证治疗组口服平肝潜阳天宁饮，风痰瘀阻兼气血亏虚证治疗组口服益气养血天宁饮，风痰瘀阻兼肝肾阴虚证治疗组口服补益肝肾天宁饮，对照组均予口服盐酸氟桂利嗪胶囊。1个疗程为15 d，连续用药2个疗程。观察两组同一证型患者用药前后头痛症状的缓解情况，中医证候疗效及血液流变学指标的变化。结果：治疗后4个证型两组患者头痛症状总积分较治疗前显著下降（P<0.01），治疗组优于对照组（P<0.01）。治疗组患者4个证型中医证候疗效的总有效率均高于对照组（P<0.05）。两组患者治疗后4个证型的总体血液流变学指标均有所下降（P<0.05，P<0.01），治疗组优于对照组（P<0.05，P<0.01）。两组患者在治疗期间均未见不良反应。结论：天宁饮类方可明显改善不同证型偏头痛患者的头痛症状，作用机制与改善偏头痛患者的血黏度有关。

Abstract

Objective:To investigate the clinical efficacy and possible mechanism of Tianning drink associated prescriptions for migraine through the observation of effects on headache and hemorheological indexes in migraine patients with different syndrome types. Method:The 216 patients with migraine were randomized into treatment group (108 cases) and control group (108 cases). 1 case was removed and 15 cases withdrew from the study

with 200 effective cases finally (100 cases in each group). Then they were divided into wind-phlegm and blood stasis treatment group (22 cases)

wind-phlegm and blood stasis control group (20 cases)

wind-phlegm and blood stasis with hyperactivity of liver-Yang treatment group (44 cases)

wind-phlegm and blood stasis with hyperactivity of liver-Yang control group (48 cases)

wind-phlegm and blood stasis with deficiency of Qi and blood treatment group (19 cases)

wind-phlegm and blood stasis with deficiency of Qi and blood control group (17 cases)

wind-phlegm and blood stasis with deficiency of liver and kidney treatment group (15 cases) and wind-phlegm and blood stasis with deficiency of liver and kidney control group (15 cases). Treatment groups

patients with wind-phlegm and blood stasis were treated with Tianning drink; wind-phlegm and blood stasis with hyperactivity of liver-Yang were treated with Pinggan Qianyang Tianning drink; wind-phlegm and blood stasis with deficiency of Qi and blood were treated with Yiqi Yangxue Tianning drink; wind-phlegm and blood stasis with deficiency of liver and kidney were treated with Buyi Ganshen Tianning drink. While the cases in control group were treated with oral flunarizine capsules. Fifteen days were one period of treatment and there were two successive periods. Then the improvement of headache symptoms

comprehensive efficacy and the changes of hemorheology were observed. Result:The clinical symptom scores were both decreased after treatment

and treatment group was superior to control group (P<0.01). The total effective rates of the four syndromes of treatment groups were higher than those of control group (P<0.05

P<0.01). The hemorheological indexes of the four syndromes were decreased after treatment

and treatment group was superior to control group (P<0.05

P<0.01). Conclusion:Tianning drink associated prescriptions can significantly improve the symptoms of migraine in patients with different syndromes

and the possible mechanism may be associated with regulating blood viscosity of such patients.

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