翁沥通胶囊联合针刺治疗慢性前列腺炎/慢性骨盆疼痛综合征湿热瘀滞证的临床疗效

王德军; 李路凯; 张辉

doi:10.13422/j.cnki.syfjx.2018030208

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翁沥通胶囊联合针刺治疗慢性前列腺炎/慢性骨盆疼痛综合征湿热瘀滞证的临床疗效

临床 | 更新时间：2024-01-04

- 翁沥通胶囊联合针刺治疗慢性前列腺炎/慢性骨盆疼痛综合征湿热瘀滞证的临床疗效
- Clinical Effect of Wenglitong Capsule Combined with Acupuncture in Treating CP/CPPS with Damp Heat Stasis Syndrome
- 中国实验方剂学杂志 2018年24卷第3期页码：208-213
- 作者机构：
- 作者简介：
- 基金信息：
  
  河南省中医药科学研究专项（2016ZY3014）
- DOI：10.13422/j.cnki.syfjx.2018030208
  中图分类号： R277.5
- 纸质出版日期：2018
- 稿件说明：
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王德军, 李路凯, 张辉. 翁沥通胶囊联合针刺治疗慢性前列腺炎/慢性骨盆疼痛综合征湿热瘀滞证的临床疗效[J]. 中国实验方剂学杂志, 2018,24(3):208-213.

WANG De-jun, LI Lu-kai, ZHANG Hui. Clinical Effect of Wenglitong Capsule Combined with Acupuncture in Treating CP/CPPS with Damp Heat Stasis Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(3): 208-213.
王德军, 李路凯, 张辉. 翁沥通胶囊联合针刺治疗慢性前列腺炎/慢性骨盆疼痛综合征湿热瘀滞证的临床疗效[J]. 中国实验方剂学杂志, 2018,24(3):208-213. DOI： 10.13422/j.cnki.syfjx.2018030208.

WANG De-jun, LI Lu-kai, ZHANG Hui. Clinical Effect of Wenglitong Capsule Combined with Acupuncture in Treating CP/CPPS with Damp Heat Stasis Syndrome[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(3): 208-213. DOI： 10.13422/j.cnki.syfjx.2018030208.

摘要

目的：观察翁沥通胶囊联合针刺的方案治疗慢性前列腺炎/慢性骨盆疼痛综合征（CP/CPPS）湿热瘀滞证临床疗效，及对前列腺液（EPS）炎症因子的影响。方法：将140例患者采用随机按数字表法分为对照组和观察组各70例。对照组采用针刺治疗，观察组在对照组治疗的基础上给予翁沥通胶囊，3粒/次，2次/d，口服。两组疗程均为6周。进行治疗前后美国国立卫生研究院的CP症状指数（NIH-CPSI）评分和中医证候评分；进行治疗前后患者健康问卷-抑郁量表（PHQ）评分和疼痛灾难化量表（PCS）评分；进行治疗前后EPS常规检查；检测治疗前后EPS白细胞介素-1β（IL-1β），肿瘤坏死因子-α（TNF-α），干扰素-γ（IFN-γ），白细胞介素-2（IL-2）水平。结果：观察组临床疗效总有效率为97.01%，高于对照组的86.15%（χ2＝5.095，P<0.05）；观察组中医证候疗效总有效率为97.01%，高于对照组的83.08%（χ2=7.219，P<0.05）；治疗后观察组患者排尿症状、生活质量评分及NIH-CPSI总分均低于对照组（P<0.01）；观察组尿路症状、放射痛症状、性功能障碍、全身症状评分及湿热瘀滞证总分均低于对照组（P<0.01）；治疗后观察组EPS中卵磷脂小体的改善优于对照组（P<0.05）；治疗后观察组PCS评分低于对照组（P<0.01）；治疗后观察组患者EPS中IL-1β，TNF-α，IFN-γ水平均低于对照组，IL-2水平高于对照组（P<0.01）。结论：翁沥通胶囊联合针刺治疗CP/CPPS （湿热瘀滞证）能显著改善患者的症状，减轻焦虑、抑郁，增加EPS中卵磷脂小体，并能抑制炎症反应，减轻炎性损伤，疾病疗效和中医证候疗效均具有明显优势，二者的联合具有协同作用。

Abstract

Objective:To observe the clinical effect of Wenglitong capsule combined with acupuncture in treating chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) with damp heat stasis syndrome

and its impact on inflammatory factors of prostatic secretions (EPS). Method:One hundred and forty patients were divided into control group and observation group by random number table. Patients in control group got acupuncture. In addition to the therapy of control group

patients in observation group was also given Wenglitong capsule

3 grains/time

2 times/day. A course of treatment was six weeks. Before and after treatment

scores of CP Symptom Index of National Institutes of Health (NIH-CPSI) and traditional Chinese medicine(TCM) syndromes

patient health questionnaire (PHQ) and pain catastrophizing scale (PCS) were graded. EPS were detected. And levels of interleukin-1β (IL-1β)

interleukin-2 (IL-2)

tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) were also detected. Result:The total effect rate in observation group was 97.01%

which was higher than 86.15% in control group (χ2=5.095

P<0.05). And the total effect rate of TCM symptoms in observation group was 97.01%

which was higher than 83.08% in control group (χ2=7.219

P<0.05). After treatment

scores of urination symptoms

quality of life

NIH-CPSI and PCS in observation group were all lower than those in control group (P<0.01). Scores of urinary tract symptoms

radiating pain symptoms

sexual dysfunction

evaluation of systemic symptoms and damp heat stasis syndrome were all lower than those in control group (P<0.01). Lecithin body of EPS in observation group was superior to that in control group (P<0.05). And levels of IL-1β

TNF-α

IFN-γ were all lower than those in control group

and the level of IL-2 was higher than that in control group (P<0.01). Conclusion:Wenglitong capsule combined with acupuncture can ameliorate symptoms of patients with CP/CPPS

relieve anxiety and depression

increase lecithin body of EPS

inhibit inflammation

and reduce inflammatory damage

with a better efficacy and TCM symptoms. Due to their good synergy.

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