Objective: To compare the similarities and differences of intestinal absorption kinetics and pharmacokinetics between baicalin magnesium salt and baicalin. Method: HPLC was employed to determine the contents of baicalin magnesium salt and baicalin in samples

and the intestinal absorption kinetics parameters

such as absorption rate constant(Ka)

intestinal absorption per unit volume within one hour(Abs)

apparent permeability coefficient(Papp) and pharmacokinetics parameters such as the bioavailability (AUC0-t) were figured out.That was not only clarified the behaviors of baicalin magnesium salt

but also discussed the differences of the absorption of baicalin magnesium salt and baicalin in vivo and in suit by SPSS 19.0 statistical software. Result: The Ka

Abs and Papp of baicalin magnesium salt were 16.33

1.78

15.75 times than these of baicalin with significant difference (P<0.05).However

these pharmacokinetic data showed that AUC0-t of baicalin magnesium salt had no significant differences by comparing with baicalin

as well as parameters of Cmax

Tmax and CLz. Conclusion: The intestinal absorption of baicalin magnesium salt in whole intestine tract of rats is better and quicker than baicalin.Meanwhile

pharmacokinetic characteristics of baicalin magnesium salt after oral administration are not significantly different from these of baicalin

because it can be reduced into baicalin under the action of gastric acids in the body.