Objective: To observe the effect of Qishen Yiqi dripping pill on cardiac function

collagen I (Col Ⅰ)

collagen Ⅲ(Col Ⅲ)

matrix metalloproteinase-9 (MMP-9)

proliferating cell nuclear antigen (PCNA)

α-smooth muscle actin (α-SMA) and vimentin in rats after myocardial infarction. Method: Male Wistar rats were randomly divided into five groups (n=10): sham-operation group

model group

Qishen Yiqi dripping pill (135 mg·kg-1·d-1) group (QSYQ-N)

Qishen Yiqi dripping pill (270 mg·kg-1·d-1) group (QSYQ-H) and captopril group. The sham-operation group was not ligated after threading. The left anterior descending coronary artery was ligated to establish the myocardial infarction model in the remaining groups. The model was evaluated by electrocardiograph(ECG). Rats were fed for 4 weeks. After 4 weeks

the hemodynamic state of rats was recorded by physiological recorder. The immunohistological method was used to detect myocardial Col Ⅰ

Col Ⅲ and PCNA

α-SMA

Vimentin expression in rats

and the enzyme linked immunosorbent assay (ELISA) was used to detect MMP-9 concentration in rat serum. Result: Compared with the sham-operation group

+dp/dtmax

-dp/dtmax and LVSP in the model group were significantly lower

while LVEDP was significantly elevated (P<0.01). Expressions of myocardial Col Ⅰ

Col Ⅲ and PCNA

α-SMA

Vimentin in the model group were increased

and serum MMP-9 concentration was increased (P<0.01). Compared with the model group

+dp/dtmax

-dp/dtmax

LVSP in QSYQ-N

QSYQ-H and captopril groups were elevated (P<0.05

P<0.01)

while LVEDP in QSYQ-H and captopril groups was lower (P<0.05

P<0.01). Expressions of myocardial Col Ⅰ

Col Ⅲ and PCNA

α-SMA

Vimentin in QSYQ-N

QSYQ-H and captopril groups were down-regulated

and serum MMP-9 concentration decreased (P<0.05

P<0.01). Conclusion: Qishen Yiqi dripping pill can improve cardiac systolic and diastolic function in rats after myocardial infarction

and its mechanism might be correlated with the inhibition of deposition of collagen

the degradation of matrix metalloproteinase and the proliferation and differentiation of fibroblasts and myofibroblasts.