Objective: To study the effect of Qinhuang mixture on the life quality and immune function of patients with non-Hodgkin lymphoma with syndrome of intermingled deficiency and excess. Method: By the Real World Study method

patients were divided into observation group and control group according to their own willing. All patients received routine chemotherapy and followed up at Ruijin Hospital during January 2015 and December 2016.Patients in observation group took Qinhuang mixture during routine chemotherapy and follow-up period

while patients in control group did not take Qinhuang mixture. The observation period was 6 months. Kanofsky score (KPS)

quality of life score (EORTC-QLQ-C30)

peripheral blood cell immunity

humoral immunity and immune-related cytokine levels were compared between two groups after all patients reached the end of the study. Result: A total of 222 valid cases were collected. Specifically

74 cases were in the observation group

including 20 cases in chemotherapy and 54 cases in the follow-up period; and 148 cases were in control group

including 87 cases in the chemotherapy period and 61 cases in the follow-up period. The improvement rate of KPS score in observation group was significantly superior to that in control group (P<0.05). Scores of fatigue

constipation and diarrhea in EORTC-QLQ-C30 in observation group were lower than those in control group (P<0.05). Physical

emotional function and overall health status scores of observation group were higher than those of the control group (P<0.05). Levels of CD3+

CD4+

CD4+/CD8+ ratio

immunoglobulin G (IgG)

immunoglobulin M (IgM)

interleukin (IL)-2 and alexin C3 in peripheral blood of the observation group were higher than those in control group (P<0.05)

whereas IL-6

IL-8 and IL-10 were lower than those in control group (P<0.05). Conclusion: Qinhuang mixture can effectively improve the quality of life and immune function of patients with non-Hodgkin lymphoma with syndrome of intermingled deficiency and excess.