Objective:To study the chemical constituents of Stachys geobombycis. Method:S. geobombycis crushed into coarse powder

extracted by 95% ethanol

concentrated under reduced pressure

and then its ethyl acetate and n-butanol extract was gained by fractional extraction. Chemical constituents were isolated and purified by column chromatography with silica gel

Sephadex LH-20

and semi-preparative HPLC. Their structures were elucidated by spectral data and physicochemical properties. Result:Twelve compounds were obtained and identified as:acteoside (1)

isoverbascoside (2)

p-hydroxy-benzonic acid (3)

latifolicinin C (4)

papuline (5)

linoleic acid methyl ester (6)

α-linoleic acid (7)

3

4-dihydroxybenzaldehyde (8)

uridine (9)

methyl 3

4-dihydroxy-benzoate (10)

β-sitosterol (11) and stigmasterol (12). Conclusion:Compounds 5

10 and 11 were isolated from this genus for the first time

compounds 1-4

6-9 and 12 were isolated from S. geobombycis for the first time.