Objective:To investigate the glucose and lipid-lowering effects and mechanisms of Lianmei granule. Method:Experimental rat models of type 2 diabetes were induced by high-fat diets combined with small-dose streptozotocin

and treated with Lianmei granule. Fasting blood glucose (FBG)

urine glucose

glycosylated hemoglobin (GHb)

total cholesterol (TC)

triglyceride (TG)

serum insulin (Ins)

lactoperoxidase(LPO)

superoxide dismutase(SOD) and pancreatic histopathological findings were determined. Result:Compared with control group

blood glucose was significantly decreased by Lianmei granule at low

middle and high doses (P<0.05

P<0.01). At week 9

blood glucose (P<0.01) and urine glucose (P<0.05

P<0.01) were significantly decreased by Lianmei granule at low

middle and high doses. Middle and high doses could notably reduce glycosylated hemoglobin (P<0.01)

and the middle dose could lower the insulin resistance index (P<0.05). Lianmei granule at low

mid and high doses could significantly increase the superoxide dismutase activity (P<0.05)

and reduce the plasma peroxidative lipid (P<0.05). Pathological results showed that pancreatic tissue structure score

cell vacuolation score of rats in low

middle and high-dose Lianmei granule groups had decreased; the data of islet score and proportions of β-cell score had no significant difference; total score of islet had decreased substantially. Conclusion:Lianmei granule could effectively lower blood glucose

urine glucose

blood fat and glycosylated hemoglobin of diabetic rats by alleviating insulin resistance

elevating insulin susceptibility and resisting oxygen free radicals to achieve the modulating effect on blood glucose and blood lipids.