小青龙汤联合膀胱经姜疗辨证治疗肺胀外寒内饮临床疗效

程怡; 黄少君; 范良; 卢保强; 潘小丹; 黄琼莲; 林月华; 傅汝梅

doi:10.13422/j.cnki.syfjx.2018050160

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小青龙汤联合膀胱经姜疗辨证治疗肺胀外寒内饮临床疗效

临床 | 更新时间：2024-01-04

- 小青龙汤联合膀胱经姜疗辨证治疗肺胀外寒内饮临床疗效
- Clinical Efficacy of Dialectical Therapy of Xiao Qinglongtang Combined with Bladder Meridian Ginger Therapy on Lung Distension with Syndrome of External Cold and Internal Fluid Based
- 中国实验方剂学杂志 2018年24卷第5期页码：160-165
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家中医药管理局2013年度全国名老中医专家传承工作室建设项目（2013-47）;海南省自然科学基金项目（817388，817389）;2015年度海南省卫生计生行业科研项目[琼卫科教（2015）9号];海南省社会发展科技专项资金项目（ZDYF2017109）
- DOI：10.13422/j.cnki.syfjx.2018050160
  中图分类号： R256.14
- 纸质出版日期：2018
- 稿件说明：
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程怡, 黄少君, 范良, 等. 小青龙汤联合膀胱经姜疗辨证治疗肺胀外寒内饮临床疗效[J]. 中国实验方剂学杂志, 2018,24(5):160-165.

CHENG Yi, HUANG Shao-jun, FAN Liang, et al. Clinical Efficacy of Dialectical Therapy of Xiao Qinglongtang Combined with Bladder Meridian Ginger Therapy on Lung Distension with Syndrome of External Cold and Internal Fluid Based[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(5): 160-165.
程怡, 黄少君, 范良, 等. 小青龙汤联合膀胱经姜疗辨证治疗肺胀外寒内饮临床疗效[J]. 中国实验方剂学杂志, 2018,24(5):160-165. DOI： 10.13422/j.cnki.syfjx.2018050160.

CHENG Yi, HUANG Shao-jun, FAN Liang, et al. Clinical Efficacy of Dialectical Therapy of Xiao Qinglongtang Combined with Bladder Meridian Ginger Therapy on Lung Distension with Syndrome of External Cold and Internal Fluid Based[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(5): 160-165. DOI： 10.13422/j.cnki.syfjx.2018050160.

摘要

目的：以傅汝梅教授论治肺胀学术思想为指导，探讨小青龙汤辨治联合膀胱经姜疗治疗肺胀外寒内饮证的临床疗效及对血清炎症因子的影响。方法：将116例住院患者采用SAS软件生成，随机按住院先后顺序分为对照组和观察组各58例。两组患者均给予控制感染、支气管扩张剂、氧疗、祛痰止咳及对证支持等处理。对照组采用膀胱经姜疗，观察组采用小青龙汤辨治联合膀胱经姜疗；两组疗程均为连续治疗14 d。进行治疗前后慢阻肺患者自我评估测试（CAT），外寒内饮证，6 min步行距离（6 MWD）和BODE指数评分，测量治疗前后血氧分压（PaO2），二氧化碳分压（PaCO2），血氧饱和度（SaO2），第1秒用力呼气容积（FEV1），第1秒用力呼气容积占预计值百分比（FEV1%）和第1秒用力呼气容积占用力肺活量的比值（FEV1/FVC%）指标，检测治疗前后血清降钙素原（PCT），白细胞介素-8（IL-8），肿瘤坏死因子-α（TNF-α），血清淀粉样蛋白A（SAA）水平。结果：治疗后观察组临床疗效总有效率为96.55%，高于对照组的84.48%（χ2=4.92，P<0.05）；治疗后观察组患者CAT，外寒内饮证和BODE指数评分均低于对照组（P<0.01），6 MWD距离长于对照组（P<0.01）；观察组患者PaO2和SaO2水平均高于对照组，PaCO2水平低于对照组（P<0.05）；观察组患者FEV1，FEV1%和FEV1/FVC%水平均高于对照组（P<0.05）；观察组患者血清PCT，SAA，IL-8和TNF-α水平均低于对照组（P<0.01）。结论：小青龙汤辨治联合膀胱经姜疗治疗肺胀外寒内饮证，能改善患者临床症状，增强肺功能和活动能力，减轻气流受限程度，控制炎症反应，提高临床疗效。

Abstract

Objective:To discuss the clinical efficacy of dialectical therapy of Professor Fu Rumei's Xiao Qinglongtang combined with the therapy of applying ginger at urinary bladder meridian on pulmonary distention with excessive dyspnea with syndrome of external cold and internal fluid

and its effect on serum inflammatory factors. Method:One hundred and sixteen patients were randomly into control group (58 cases) and observation group (58 cases) by random number table. Both groups' patients were treated with infection control

bronchodilator

oxygen therapy

expectorant and cough medicine

and symptomatic supportive treatment. Patients in control group got treatment of ginger acting at urinary bladder meridian. And patients in observation group got Xiao Qinglongtang combined with the therapy of applying ginger at urinary bladder meridian. A course of treatment was 14 days. Before and after treatment

self-assessment test of chronic obstructive pulmonary disease (CAT)

excessive dyspnea with syndrome of external cold and internal fluid

six-minutes' walk distance (6 MWD) and BODE were scored. Levels of partial pressure of oxygen (PaO2)

partial pressure of carbon dioxide (PaCO2)

blood oxygen saturation (SaO2)

the 1st-second forced vital capacity (FEV1)

percentage of 1st-second forced vital capacity in estimated value (FEV1%) and ratio of FEV1 to forced vital capacity (FEV1/FVC%) were calculated. And levels of procalcitonin (PCT)

interleukin-8 (IL-8)

tumor necrosis factor-α (TNF-α)

serum amyloid A (SAA) were detected. Result:The total effective rate in observation group was 96.55%

which was higher than 84.48% in control group (χ2=4.921

P<0.05). After treatment

scores of CAT

excessive dyspnea with syndrome of external cold and internal fluid

and BODE in observation group were all lower than those in control group (P<0.01)

while 6 MWD in observation group was longer than that in control group (P<0.01). Levels of PaO2

SaO2

FEV1

FEV1% and FEV1/FVC% in observation group were higher than those in control group

whereas PaCO2

PCT

SAA

IL-8 and TNF-α in observation group were lower than that in control group (P<0.05

P<0.01). Conclusion:Dialectical therapy of Xiao Qinglongtang combined with the therapy of applying ginger at urinary bladder meridian can ameliorate clinical symptoms

improve pulmonary function and activity

relieve limited degree of airflow and control inflammation

with an obvious clinical effect.

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