Objective:To observe the clinical efficacy of Chaiqin Yiwei decoction on chronic superficial gastritis (CSG) with liver-stomach disharmony and to discusses its mechanism of treatment. Method:The 130 CSG patients with liver-stomach disharmony treated in Department of Spleen and Stomach of the Hebei Province Hospital of Traditional Chinese Medicine(TCM) from January

2015 to January

2017 were divided into 2 groups according to the random number table

with 65 cases in each group. Patients in treatment group were given with Chaiqin Yiwei decotion by oral administration

1 dose/day. The patients in control group were given with conventional western medicine such as hydrotalcite tablets

rabeprazole sodium enteric-coated capsules and mosapride citrate tablets

and all patients were treated for 4 weeks in both groups. The main TCM syndrome scores

peripheral blood T lymphocyte subsets

gastric mucosa cyclooxygenase-2 (COX-2) expression and gastroscope observation before and after treatment were compared in two groups

and the effective rate of gastroscope observation

effective rate of pathology and total clinical effective rate were compared between these two groups. Result:There was not statistically significant difference in the main TCM syndrome score

peripheral blood T lymphocyte subsets and gastric mucosa COX-2 expression before treatment. As compared with before treatment

the main TCM syndrome score was decreased

CD3+

CD4+ and CD4+/CD8+ ratio were increased

and gastric mucosa COX-2 expression was reduced in both groups after treatment (P<0.01). As compared with the control group

the scores in stomach duct pain

abdominal fullness and distention

chest distress and eructation were lower

peripheral blood CD3+

CD4+

CD4+/CD8+ were higher

and gastric mucosa COX-2 expression was lower in treatment group (P<0.01). The effective rates of gastroscope observation

pathology and total clinical effective rate in treatment group were all higher than those of control group (P<0.05). Conclusion:Chaiqin Yiwei decoction can relieve patients' symptoms

with clear efficacy for CSG with liver-stomach disharmony

and its mechanism may be related to regulating the body's immune system and inhibiting inflammation of gastric mucosa.