Objective:To investigate the effect of nourishing spleen andkidney method combined with prednisone acetate tablets on bone metabolism

urine β2-microglobulin (β2-MG) and α1-microglobulin (α1-MG) of pediatric nephrotic syndrome (NS). Method:The 68 children with NS in our hospital from January 2014 to January 2016 were collected and divided into research group and control group in accordance with the admission number and random number table

34 cases in each group. The control group was given with basic treatment and prednisone treatment

and the research group additionally received nourishing kidney and spleen method treatment on the basis of treatment in control group. The treatment course was 3 months in both groups. Before and after treatment

the serum albumin

osteocalcin N-terminal molecular fragment(N-MID)

bone glaprotein(BGP)

porathroid hormone(PTH)

bone specific alkaline phosphatase(BALP)

and 24 h urinary protein were measured; the efficacy of two groups was observed; the adverse reactions were recorded; and the recurrence was recorded in one year follow up. Result:There was no significant difference in total effective rate between two groups. After treatment

traditional Chinese medicine(TCM) symptom scores were significantly reduced in both groups (P<0.05)

and the TCM symptom scores in research group were lower than those in control group(P<0.05). Calcitonin N-MID and BGP levels were significantly increased in research group (P<0.05)

and the BALP and PTH levels were decreased obviously (P<0.05)

and N-MID

BGP levels in research group were significantly higher

while BALP

PTH levels were significantly lower than those in control group after treatment (P<0.05). The urine β2-MG and α1-MG levels were significantly decreased in both groups (P<0.05)

and those levels in research group were higher than those in control group (P<0.05). The serum albumin was increased significantly in both groups (P<0.05)

and 24 h protein content was significantly decreased (P<0.05). The serum albumin level in research group was higher than that in control group after treatment (P<0.05)

and 24 h protein content was lower than that in control group (P<0.05). There was no significant difference in incidence of adverse reactions between two groups. In 1 year follow-up

the recurrence rate was 17.65% (6/34) in research group

lower than 47.06% (16/34) in the control group (P<0.05). Conclusion:Nourishing spleen and kidney method combined with prednisone acetate tablets is effective in treating pediatric nephrotic syndrome. It can relieve clinical symptoms

improve bone metabolism

regulate urine β2-MG and α1-MG

protect kidney injury and reduce the recurrence rate.