Objective: A near-infrared method for determining the uniformity of micro-borneol in the production process of compound Danshen tablets was investigated.Method: The raw materials required for the mixing process were collected and prepared into different fractions according to a certain ratio

two ways of grinding and spraying were used to mix borneol into the dry extract.Uniform samples were sampled at different locations

the samples were scanned by near-infrared

and their thresholds and Euclidean distance parameters were calculated.The content of borneol in each sample was detected by GC.Result: When the threshold or the Euclidean distance was <0.01

GC results showed that RSD of borneol content was <10%

indicating that the borneol was uniformly mixed.When the threshold or the Euclidean distance was >0.01

GC results showed that RSD of borneol content was >30%

indicating that the borneol was mixed unevenly.Conclusion: The established method can effectively and quickly determine the uniformity of borneol mixing in compound Danshen tablets

it is recommended to be incorporated into internal control or national standards.