Objective: To compare the effects of several pharmaceutic adjuvants(dextrine

amylum solubila

mannitol

microcrystalline cellulose) and their different proportions on the powder properties of Qingdu Xiaoyu granules

and to screen optimum granulating process of this granules.Method: Taking hygroscopicity

mobility

formability and dissolubility as indexes

powder research method was used to screen optimum pharmaceutic adjuvants and their proportions

on this basis

orthogonal test was used to optimize granulating process.Result: The optimum granulating process was mixing the extract with mixed pharmaceutic adjuvants of dextrine-mannitol(1:1)at 1:2

injecting 85% ethanol into the mixture with the amount of 13%.Under these conditions

the forming rate

angle of repose

equilibrium moisture absorption rate and dissolution rate of Qingdu Xiaoyu granules were 94.01%

33.72 degree

3.562% and 97.3% with RSD of 0.6%

1.6%

1.7% and 1.9%

respectively.Conclusion: The moisture blocking effect of mannitol is excellent

and the granules prepared by dextrine and mannitol has high mobility

high formability

high dissolubility and low hygroscopicity.In addition

mannitol can effectively improve the taste of the granules.The optimum granulating process is feasible

stable and suitable for industrial production.