五虎汤加减联合阿奇霉素序贯疗法治疗痰热闭肺型小儿支原体肺炎疗效及对抗炎、促炎因子及呼吸功能的影响

王勤; 张小方; 张爱娥

doi:10.13422/j.cnki.syfjx.20180620

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五虎汤加减联合阿奇霉素序贯疗法治疗痰热闭肺型小儿支原体肺炎疗效及对抗炎、促炎因子及呼吸功能的影响

临床 | 更新时间：2024-01-04

- 五虎汤加减联合阿奇霉素序贯疗法治疗痰热闭肺型小儿支原体肺炎疗效及对抗炎、促炎因子及呼吸功能的影响
- Clinical Efficacy of Modified Wuhutang Combined with Azithromycin Sequential Therapy on Anti-inflammatory, Proinflammatory Cytokines and Respiratory Function of Mycoplasmal Pneumoniae Pneumonia Children with Symptom of Phlegm-heat Obstructing Lung
- 中国实验方剂学杂志 2018年24卷第8期页码：154-158
- 作者机构：
- 作者简介：
- 基金信息：
  
  河南省科技攻关计划项目（0324420083，122102310472）;河南中医学院科技创新团队支持计划项目（2010XCXTD11）
- DOI：10.13422/j.cnki.syfjx.20180620
  中图分类号： R725.6
- 纸质出版日期：2018
- 稿件说明：
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王勤, 张小方, 张爱娥. 五虎汤加减联合阿奇霉素序贯疗法治疗痰热闭肺型小儿支原体肺炎疗效及对抗炎、促炎因子及呼吸功能的影响[J]. 中国实验方剂学杂志, 2018,24(8):154-158.

WANG Qin, ZHANG Xiao-fang, ZHANG Ai-e. Clinical Efficacy of Modified Wuhutang Combined with Azithromycin Sequential Therapy on Anti-inflammatory, Proinflammatory Cytokines and Respiratory Function of Mycoplasmal Pneumoniae Pneumonia Children with Symptom of Phlegm-heat Obstructing Lung[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(8): 154-158.
王勤, 张小方, 张爱娥. 五虎汤加减联合阿奇霉素序贯疗法治疗痰热闭肺型小儿支原体肺炎疗效及对抗炎、促炎因子及呼吸功能的影响[J]. 中国实验方剂学杂志, 2018,24(8):154-158. DOI： 10.13422/j.cnki.syfjx.20180620.

WANG Qin, ZHANG Xiao-fang, ZHANG Ai-e. Clinical Efficacy of Modified Wuhutang Combined with Azithromycin Sequential Therapy on Anti-inflammatory, Proinflammatory Cytokines and Respiratory Function of Mycoplasmal Pneumoniae Pneumonia Children with Symptom of Phlegm-heat Obstructing Lung[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(8): 154-158. DOI： 10.13422/j.cnki.syfjx.20180620.

摘要

目的：探讨五虎汤加减联合阿奇霉素序贯疗法治疗痰热闭肺型小儿支原体肺炎（mycoplasmal pneumoniae pneumonia，MPP）临床疗效及安全性。方法：以河南中医药大学第二附属医院在2015年3月-2016年12月收治的135例MPP患儿作为研究对象，随机数字表法分为治疗组（67例）、对照组（68例）。对照组MPP患儿应用阿奇霉素序贯疗法进行治疗，治疗组联合五虎汤加减进行治疗，清水煎煮，每日1剂，连续治疗14 d后，对比两组患儿临床疗效及治疗前后抗炎、促炎因子及呼吸功能的变化情况。结果：治疗组患者总有效率为94.03%，对照组为85.29%，治疗组高于对照组（P<0.05）；与治疗前比较，治疗后，两组患儿血清中白细胞介素-2（interleukin-2，IL-2）水平明显升高，且治疗组明显高于对照组（P<0.05），白细胞介素-4（interleukin-4，IL-4），白细胞介素-10（interleukin-10，IL-10）水平明显降低，且治疗组低于对照组（P<0.05）；与本组治疗前比较，治疗后两组患儿血清中肿瘤坏死因子（tumor necrosis factor，TNF）-α，白细胞介素-6（interleukin-6，IL-6）与白细胞介素-8（interleukin-8，IL-8）水平均明显降低，且治疗组低于对照组（P<0.05）；与本组治疗前比较，治疗后两组患儿动脉氧分压（arterial oxygen partial pressure，PaO2），氧合指数（PaO2/FiO2）水平明显升高，且治疗组高于对照组（P<0.05），呼吸频率（respiratory rate，RR）明显降低，且治疗组低于对照组（P<0.05）；两组不良反应比较差异无统计学意义。结论：五虎汤加减联合阿奇霉素治疗痰热闭肺型MPP患儿疗效显著，可明显改善患儿抗炎/促炎因子失衡情况与呼吸功能，安全性较好。

Abstract

Objective: To study the clinical efficacy and safety of modified Wuhutang combined with azithromycin sequential therapy on anti-inflammatory

proinflammatory cytokines and respiratory function of mycoplasmal pneumoniae pneumonia children (MPP) with symptom of phlegm-heat obstructing lung. Method: Totally 135 cases MPP children treated in our hospital from March 2015 to December 2016 were selected and divided into two groups according to the admitted order

with 67 cases in clinical group and 68 cases in control group. Patients in control group were treated with azithromycin sequential therapy

while the clinical group was additionally given Wuhutang

which was decocted with clear water

one dose a day. Then the clinical efficacy

anti-inflammatory cytokines

proinflammatory cytokines and respiratory function of the two groups were compared after treatment for 14 days. Result: Compared with 85.29% in control group

the total effective rate of clinical group was 94.03%

with significant differences (P<0.05). Compared with before treatment

interleukin (IL)-4 and IL-10 of two groups decreased after treatment

while IL-2 increased (P<0.05). Compared with control group

the levels of IL-4 and IL-10 in patients of experimental group were lower after treatment

while IL-2 was higher (P<0.05). Comparison of the levels of IL-6

tumor necrosis factor (TNF)-α and IL-8 before and after treatment between the two groups showed significant differences. The levels of inflammatory factors in treatment group were lower than those in control group (P<0.05). Compared with before treatment

RR of two groups decreased after treatment

while arterial oxygen partial pressure (PaO2) and PaO2/FiO2 increased (P<0.05). Compared with control group

the respiratory rate (RR) in patients of experimental group was lower after treatment

while PaO2 and PaO2/FiO2 were higher (P<0.05). Conclusion: Modified Wuhutang is very effective in treating MPP. It can significantly improve the serum inflammatory factors

proinflammatory cytokines and respiratory function.

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