骨痹方治疗膝骨关节炎肾虚络痹证临床观察

袁芳; 何晓瑾; 石俊; 朱琳; 周逸群

doi:10.13422/j.cnki.syfjx.20180621

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骨痹方治疗膝骨关节炎肾虚络痹证临床观察

临床 | 更新时间：2024-01-04

- 骨痹方治疗膝骨关节炎肾虚络痹证临床观察
- Effect of Gubi Recipe in Treating Knee Osteoarthritis with Symptom of Kidney Deficiency and Collateral Obstruction
- 中国实验方剂学杂志 2018年24卷第7期页码：207-211
- 作者机构：
- 作者简介：
- 基金信息：
  
  江苏省自然科学基金项目（BK20131419）;江苏省2016年高层次卫生人才“六个一工程”科研项目（LGY2016014）
- DOI：10.13422/j.cnki.syfjx.20180621
  中图分类号： R274.9
- 纸质出版日期：2018
- 稿件说明：
移动端阅览
袁芳, 何晓瑾, 石俊, 等. 骨痹方治疗膝骨关节炎肾虚络痹证临床观察[J]. 中国实验方剂学杂志, 2018,24(7):207-211.

YUAN Fang, HE Xiao-jin, SHI Jun, et al. Effect of Gubi Recipe in Treating Knee Osteoarthritis with Symptom of Kidney Deficiency and Collateral Obstruction[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(7): 207-211.
袁芳, 何晓瑾, 石俊, 等. 骨痹方治疗膝骨关节炎肾虚络痹证临床观察[J]. 中国实验方剂学杂志, 2018,24(7):207-211. DOI： 10.13422/j.cnki.syfjx.20180621.

YUAN Fang, HE Xiao-jin, SHI Jun, et al. Effect of Gubi Recipe in Treating Knee Osteoarthritis with Symptom of Kidney Deficiency and Collateral Obstruction[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(7): 207-211. DOI： 10.13422/j.cnki.syfjx.20180621.

摘要

目的：通过观察骨痹方对肾虚络痹证的膝骨关节炎（knee osteoarthritis，KOA）患者的临床疗效，评价其有效性及安全性。方法：本临床观察共纳入肾虚络痹证的KOA患者60例，按随机数字表法分为两组，各30例，治疗组予口服骨痹方，1剂/d，对照组予口服硫酸氨基葡萄糖，0.5 g/次，3次/d，疗程均为3个月，观察治疗前和治疗后两组膝关节疼痛视觉模拟评分法（VAS）评分，西安大略和麦克马斯特大学（WOMAC）骨关节炎指数，中医证候积分，血沉（ESR），C反应蛋白（CRP）等的变化，并比较两组中医证候疗效及疾病疗效差别，同时观察不良反应。结果：中医证候疗效比较，治疗组总有效率是100%，优于对照组的88.3%（P<0.01）。疾病疗效比较，治疗组总有效率是100%，优于对照组的76.7%（P<0.01）。与本组治疗前比较，治疗后两组患者膝部疼痛，膝部肿胀，膝关节屈伸不利，下肢乏力，腰脊酸痛，畏寒怕冷，VAS评分及WOMAC指数的关节疼痛，功能积分，僵硬积分、总积分均下降（P<0.05，P<0.01）。与对照组治疗后相比，治疗组患者膝部疼痛，膝部肿胀，膝关节屈伸不利，腰脊酸痛，畏寒怕冷，VAS评分，WOMAC指数的僵硬积分明显降低（P<0.05，P<0.01），下肢乏力及WOMAC指数的总积分、疼痛、功能积分降低不明显。活动指标比较，与本组治疗前比较，两组治疗后ESR，CRP均有改善（P<0.05，P<0.01），但两组无明显差异。结论：骨痹方可有效控制膝骨关节炎，且无明显不良反应。

Abstract

Objective: To observe the clinical efficacy of Guibi recipe on knee osteoarthritis (KOA) with symptom of kidney deficiency and collaterals obstruction

in order to evaluate the effectiveness and safety. Method: In this study

60 cases of KOA with symptom of kidney deficiency and collateral obstruction were included

and divided into treatment group (30) taking Guibi recipe and control group (30) taking glucosamine sulfate

0.5 g/times

3 times/day. The treatment source was 3 months. The changes in visual analogue scale/score (VAS)

the Western Ontario and McMaster (WOMAC) osteoarthritis index

traditional Chinese medicine (TCM) syndrome score

erythrocyte sedimentation rate(ESR) and C-reactive protein (CRP) in the two groups were observed before and after treatment

so as to compare the TCM syndrome efficacy and disease efficacy differences of the two groups; meanwhile the adverse reactions were also observed. Result: Comparison of TCM syndromes

the total effective rate in treatment group was 100%

which was higher than 88.3% in control group (P<0.01). Comparison of disease efficacy

the total effective rate in the treatment group was 100%

which was higher than 76.7% in the control group (P<0.01). Compared with before treatment

knee pain

knee swelling

knee flexion and extension

lower limb weakness

lumbar soreness

chills

VAS score and WOMAC index of joint pain

functional integral

stiffness integral and total score of the two groups of patients decreased (P<0.05

P<0.01). Compared with control group

knee pain

knee swelling

knee flexion and extension adverse

lumbar soreness

chills

VAS score

WOMAC index stiffness score of the treatment group of patients significantly reduced (P<0.05

P<0.01); lower limb weakness and total score

pain

functional score of WOMAC index slightly decreased. Activity indicators comparison

ESR

CRP of the treatment group and the control group were improved (P<0.05

P<0.01)

but with no significant difference between the two groups. Conclusion: Gubi recipe can effectively control KOA

with no obvious adverse reaction.

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