Objective: To study the clinical efficacy of Fuzheng Yiliu recipe combined with neoadjuvant chemotherapy and laparoscopic assisted radical gastrectomy in treating advanced gastric cancer. Method: Totally 106 patients with advanced gastric cancer hospitalized from January 2012 to June 2014 were selected and randomly divided into observation group and control group

with 35 cases in each group. In control group

neoadjuvant chemotherapy combined with laparoscopic assisted radical gastrectomy was provided. The neoadjuvant chemotherapy regimen was performed with FOLFOX6.The observation group was treated with Fuzheng Yiliu recipe in addition to the therapy of the control group. The clinical response rate

disease control rate

adverse reaction

Karnosfsky score

survival time

tumor recurrence and metastasis were observed and compared. The levels of CD3+

CD4+

CD8+positive T cells and NK cells (CD16+CD56+)

inflammatory cytokines tumor necrosis factor (TNF)-α

interleukin (IL)-6

C-reactive protein (CRP) and heme oxygenase (HO)-1 were detected and compared between the two groups. The levels of matrix metalloproteinases (MMP)-2

MMP-9

vascular endothelial growth factor (VEGF)-A and VEGF-C in the tumor markers carcinoembryonic antigen (CEA)

cancer antigen (CA724 and CA50) and recurrence and metastasis were observed. Result: The clinical response rate of observation group was significantly higher than that of control group (P <0.05). The disease control rate was slightly higher than that of control group

but with no statistically significant difference. The effective rate in observation group was 69.8%

which was significantly higher than 39.6% of control group (P<0.05). The levels of TNF-α

IL-6

CRP and HO-1 in two groups were significantly lower than those in control group (P<0.05). The levels of CD3+

CD4+

CD8+

CD4+/CD8+and NK cells in observation group were significantly higher than those before treatment (P<0.05)

while the levels of CEA

CA724

CA50

MMP and VEGF were significantly reduced. The incidences of leukopenia

nausea

vomiting

mucosal response and fatigue were significantly lower in observation group than those in control group (P<0.05). Conclusion: Fuzheng Yiliu recipe combined with neoadjuvant chemotherapy and laparoscopic assisted radical gastrectomy for the treatment of advanced gastric cancer patients can be significantly effective in relieving the adverse reactions caused by chemotherapy

alleviating the stress level of patients after operation

improving the immune defense function and the quality of life of patients

inhibiting tumor recurrence and metastasis

and is worth clinical application.