Objective: To investigate the clinical efficacy of traditional Chinese medicine(TCM) in the treatment of unstable angina. Method: A cohort study was performed in this study. During the period of hospitalization

the exposure group was established through the application of TCM injection for at least 7 days. During the follow-up period

the exposure group was established through the application of Chinese medicine or TCM decoction for at least 28 days. The general information

application of TCM and endpoint events of patients were collected based on the medical records during hospitalization. The application of TCM and endpoint events of patients from the date of discharge to December 31

2015 were followed up by telephone. The single factor analysis was made by chi-square test. The multivariate analysis was performed by multiple logistic regression analysis. Result: During hospitalization

top three endpoint events were revascularization (30.93%)

myocardial infarction (25.77%) and stroke (18.56%). TCM therapy (OR=2.651

CI=1.089-6.454)

age (OR=1.881

CI=0.817-2.950)

antithrombotic therapy (OR=1.088

CI=1.026-1.296)

anti-myocardial ischemia therapy (OR=1.150

CI=0.051-2.445)

and lipid-lowering therapy (OR=1.241

CI=1.085-1.683) were the factors related to myocardial infarction. TCM(OR=2.972

CI=1.113-7.930) was associated with stroke. During the follow-up period

the endpoint events were cardiovascular readmission (11.66%)

revascularization (7.13%) and stroke (3.89%). TCM(OR=1.515

CI=0.299-1.886) and age (OR=1.892

CI=0.813-1.979) were related factors of cardiac death. Conclusion: TCM

age and gender are the related factors of endpoint events in patients with unstable angina. TCM can reduce the incidences of myocardial infarction and stroke in patients with unstable angina during hospitalization

and cardiac death during the follow-up period.