Objective: To prepare standard decoction of Forsythiae Fructus and establish its quality standard. Method: Sixteen batches of standard decoction of Forsythiae Fructus were prepared according to the standardization method.With forsythin and forsythoside A as detection indexes

the transfer rates of index components and extraction rates were calculated and the HPLC fingerprint analysis method was established. Result: Through the measurement of 16 batches of standard decoction of Forsythiae Fructus

the extraction rate was ruled from 13.61% to 25.27%

the transfer rates of forsythin and forsythoside A were defined as 58.61%-100.00% and 27.88%-51.78%

respectively.Besides

the similarity evaluation system for chromatographic fingerprint of traditional Chinese medicine (version 2012) was used to analyze the fingerprint

ten common peaks were determined and six were calibrated

including forsythenside F (peak 3)

forsythoside Ⅰ (peak 4)

(+) pinoresinol 4-O-β-D-glucopyranoside (peak 5)

forsythoside A (peak 6)

forsythin (peak 7) and phillygenin (peak 10);taking the characteristic peak evaluation model

the relative retention time of each characteristic peak were defined as 0.47

0.52

0.67

0.71

1.00

1.27 with peak 7 as a reference. Conclusion: This study establishes a method for the quality evaluation of standard decoction of Forsythiae Fructus.The method is accurate

reproducible and characterized.Therefore

it can provide a reference for the quality control of Forsythiae Fructus dispensing granules.