Objective: To observe the clinical efficacy of Dizhong Qianggu capsule in the treatment of kidney and blood deficiency type postmenopausal osteoporosis and on the living quality

in order to explore its effect on the markers of bone metabolism and bone turnover. Method: Totally 120 patients in line with the diagnostic criteria for the kidney and blood deficiency type postmenopausal osteoporosis were randomly divided into two groups. The two groups were given the conventional basic therapy. The control group received alendronate sodium tablets in addition to the conventional basic therapy

while the observation group received Dizhong Qianggu capsule and alendronate sodium tablets in addition to the conventional basic therapy. After 6 months

bone mineral density (BMD)

bone metabolism indexes

bone transformation index

clinical efficacy

visual analogue scale (VAS) pain index and health status were scores. And the adverse reactions were recorded. Result: Compared with before treatment

L2-4

neck and Ward BMD indexes significantly increased (P<0.05)

index of bone transformation significantly elevated (P<0.05)

bone transformation index bone gla protein (BGP) increased

whereas type I collagen C-telopeptide (CTX-1) decreased (P<0.05)

VAS pain index descended

health status improved greatly in the control group and the observation group

with significant differences between them (P<0.05). Compared with control group

the observation group showed the increase in bone density of lumbar L2-4

bone metabolism indexes bone alkaline phosphatase (BALP)

calcitonin (CT)

estradiol (E2)

bone metabolism BALP

CT

E2 index level and bone transformation index BGP level

and the reduction in CTX-1 level and VAS pain index

with significant differences in these indicators (P<0.05). The total effective rate of the observation group was also significantly higher than that of control group. And there were a few adverse reactions. Conclusion: Dizhong Qianggu capsule has a significant efficacy in the treatment of osteoporosis

and can effectively increase BMD of the patients

and improve bone metabolism and bone turnover status. Its possible anti-osteoporosis mechanism may be correlated with the decrease of bone turnover and the inhibition of bone resorption by directly or indirectly acting on osteoblasts and osteoclasts in a multicomponent and multi-target manner.