蛇丹愈后丸联合加巴喷丁治疗气虚血瘀型带状疱疹后遗神经痛的临床观察

王丽; 方玉甫; 李庆娟; 耿庆娜; 周国秀

doi:10.13422/j.cnki.syfjx.20180721

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蛇丹愈后丸联合加巴喷丁治疗气虚血瘀型带状疱疹后遗神经痛的临床观察

临床 | 更新时间：2024-01-04

- 蛇丹愈后丸联合加巴喷丁治疗气虚血瘀型带状疱疹后遗神经痛的临床观察
- Effect of Shedan Yuhou Pill and Gabapentin in Treating Postherpetic Neuralgia with Qi and Blood Stasis
- 中国实验方剂学杂志 2018年24卷第8期页码：183-188
- 作者机构：
- 作者简介：
- 基金信息：
  
  河南省科技发展计划项目（142300410298）
- DOI：10.13422/j.cnki.syfjx.20180721
  中图分类号： R275.9
- 纸质出版日期：2018
- 稿件说明：
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王丽, 方玉甫, 李庆娟, 等. 蛇丹愈后丸联合加巴喷丁治疗气虚血瘀型带状疱疹后遗神经痛的临床观察[J]. 中国实验方剂学杂志, 2018,24(8):183-188.

WANG Li, FANG Yu-pu, LI Qing-juan, et al. Effect of Shedan Yuhou Pill and Gabapentin in Treating Postherpetic Neuralgia with Qi and Blood Stasis[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(8): 183-188.
王丽, 方玉甫, 李庆娟, 等. 蛇丹愈后丸联合加巴喷丁治疗气虚血瘀型带状疱疹后遗神经痛的临床观察[J]. 中国实验方剂学杂志, 2018,24(8):183-188. DOI： 10.13422/j.cnki.syfjx.20180721.

WANG Li, FANG Yu-pu, LI Qing-juan, et al. Effect of Shedan Yuhou Pill and Gabapentin in Treating Postherpetic Neuralgia with Qi and Blood Stasis[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(8): 183-188. DOI： 10.13422/j.cnki.syfjx.20180721.

摘要

目的：研究蛇丹愈后丸联合加巴喷丁治疗气虚血瘀型带状疱疹后遗神经痛（PHN）的疗效，探讨其可能的作用机制。方法：将114例符合条件的患者随机分为中药组，西药组和中西药组，各38例。中药组，西药组和中西药组分别口服蛇丹愈后丸，加巴喷丁，蛇丹愈后丸联合加巴喷丁，疗程均为4周。观察各组治疗前后简化McGill疼痛评分量表（McGill），皮肤病生活质量指数（DLQI）和中医辨证PHN气虚血证中医证候积分；检测血清白细胞介素-6（IL-6），白细胞介素-2（IL-2），肿瘤坏死因子-α（TNF-α），超氧化物歧化酶（SOD）含量变化；比较各组有效率，复发率和不良反应。结果：中西药组总有效率96.8%，高于中药组的78.8%和西药组的77.1%（P<0.05），中药组与西药组比较无明显差异；中西药组McGill，DLQI积分改善优于中药组和西药组（P<0.05）；中西药组和中药组中医证候积分优于西药组（P<0.05）；中西药组血清IL-6，IL-2，TNF-α，SOD水平比中药组和西药组改善更为明显（P<0.05）；随访复发率比较，中西药组 < 中药组 < 西药组（P<0.05）；不良反应发生率比较，中药组 < 中西药组 < 西药组（P<0.05）。结论：蛇丹愈后丸治疗气虚血瘀型PHN的疗效与加巴喷丁无明显差异，不良反应和复发率低，说明其安全有效；蛇丹愈后丸联合加巴喷丁治疗气虚血瘀型PHN具有协同增效的作用，且可降低加巴喷丁的不良反应。

Abstract

Objective: To explore the efficacy of Shedan Yuhou pill and gabapentin in treating postherpetic neuralgia (PHN) with Qi and blood stasis patients

in order to explore its possible mechanism. Method: A total of 114 eligible patients were randomly divided into the traditional Chinese medicine (TCM) group

the western medicine group and the TCM combined with western medicine group. The TCM group was treated with Shedan Yuhou pill; gabapentin was administered to the medicine medicine group; Shedan Yuhou pill and gabapentin were given to the TCM combined with medicine medicine group. A course of treatment was 4 weeks. The simplified McGill pain score scale (McGill)

skin disease life quality index (DLQI) and TCM syndrome PHN hemostasis syndrome (TCM syndrome) were observed to estimate the efficacy of the three group before and after treatment. The serum interleukin-6 (IL-6)

interleukin-2 (IL-2)

tumor necrosis factor-α (TNF-α)

superoxide dismutase (SOD) were detected to compare the efficiency

recurrence rate and adverse reaction in the 3 groups. Result: The efficiency of the TCM combined with western medicine group was 96.8%

which was higher than 78.8% of the TCM group and 77.1% of the western medicine group (P<0.05). After treatment

McGill

DLQI

serum IL-6

IL-2

TNF-α

SOD of the TCM combined with western medicine group improved significantly (P<0.05) in three group. The order from low to high by the efficiency and incidence of adverse reactions was the TCM group < the TCM combined with western medicine group < the western medicine group (P<0.05). Conclusion: Shedan Yuhou pill is effective in treating PHN with Qi and blood stasis

with no significant difference from gabapentin. The incidence of adverse reactions was lower. Shedan Yuhou pill combined with gabapentin has a synergistic effect

which were better than the single use of Shedan Yuhou pill or gabapentin

with a lower recurrence rate.

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