葛根交泰丸对2型糖尿病大鼠的治疗作用

李秋霞; 吴凝; 聂闪闪; 姜序吉; 王东生

doi:10.13422/j.cnki.syfjx.20180794

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葛根交泰丸对2型糖尿病大鼠的治疗作用

药理 | 更新时间：2024-01-04

- 葛根交泰丸对2型糖尿病大鼠的治疗作用
- Effect of Gegen Jiaotaiwan on Rats with Type 2 Diabetes Mellitus
- 中国实验方剂学杂志 2018年24卷第7期页码：133-138
- 作者机构：
- 作者简介：
- 基金信息：
  
  国家自然科学基金项目（81173198，81373554）;国家科技部国际合作计划项目（2010DFA32370）;国家科技支撑计划项目（2009BAI80B04）;湖南中医药大学中医诊断重点学科开放基金项目（2014-3）
- DOI：10.13422/j.cnki.syfjx.20180794
  中图分类号： R285.5
- 纸质出版日期：2018
- 稿件说明：
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李秋霞, 吴凝, 聂闪闪, 等. 葛根交泰丸对2型糖尿病大鼠的治疗作用[J]. 中国实验方剂学杂志, 2018,24(7):133-138.

LI Qiu-xia, WU Ning, NIE Shan-shan, et al. Effect of Gegen Jiaotaiwan on Rats with Type 2 Diabetes Mellitus[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(7): 133-138.
李秋霞, 吴凝, 聂闪闪, 等. 葛根交泰丸对2型糖尿病大鼠的治疗作用[J]. 中国实验方剂学杂志, 2018,24(7):133-138. DOI： 10.13422/j.cnki.syfjx.20180794.

LI Qiu-xia, WU Ning, NIE Shan-shan, et al. Effect of Gegen Jiaotaiwan on Rats with Type 2 Diabetes Mellitus[J]. Chinese journal of experimental traditional medical formulae, 2018, 24(7): 133-138. DOI： 10.13422/j.cnki.syfjx.20180794.

摘要

目的：观察不同剂量葛根交泰丸对2型糖尿病（T2DM）大鼠的治疗作用。方法：采用高糖高脂饲料喂养联合腹腔注射小剂量链脲佐菌素的方法建立T2DM大鼠模型，随机分为正常组（N组），模型组（MOD组），二甲双胍组（MET组），葛根交泰丸高（GJH），中（GJM），低（GJL）剂量（12.15，8.1，4.05 g · kg-1）组；治疗后每周测量大鼠体质量及空腹血糖（FBG），末次给药24 h后收集大鼠血清样本，比较各组大鼠血脂[总胆固醇（TC），甘油三酯（TG），高密度脂蛋白-胆固醇（HDL-C），低密度脂蛋白-胆固醇（LDL-C）]，血清肝酶[天门冬氨酸氨基转移酶（AST），丙氨酸氨基转移酶（ALT）]活性，血尿素氮（BUN），血肌酐（SCr），血尿酸（UA）的差异。结果：与N组比较，MOD组大鼠体质量减轻，FBG，TG，TC，LDL-C，ALT，AST，BUN，SCr，UA均升高，HDL-C降低（P<0.05）；与MOD组比较，各治疗组大鼠体质量均增加，FBG，TG，TC，LDL-C下降（P<0.01），MET组，GJH组和GJM组ALT，UA明显下降（P<0.05）；与MET组比较，GJH组和GJL组体质量，LDL-C下降（P<0.05），GJL组FBG，ALT，UA均升高（P<0.05），GJM组TC，LDL-C降低（P<0.01）；与GJM组比较，GJH组和GJL组体质量降低，FBG，TC，LDL-C均升高（P<0.05），GJL组ALT，UA升高（P<0.01）。结论：不同剂量的葛根交泰丸均能明显降低T2DM大鼠的血脂及血糖水平，增加大鼠体质量，抑制ALT表达，降低UA含量，可用于防治T2DM及其并发症。

Abstract

Objective: To observe the therapeutic effect of different doses of Gegen Jiaotaiwan on rats with type 2 diabetes mellitus (T2DM). Method: T2DM models were established by high fat and high glucose feeding combined with intraperitoneal injection of streptozotocin (STZ). Then the rats were randomly divided into normal group (N)

model group (MOD)

metformin group (MET)

Gegen Jiaotaiwan high-dose group (GJH)

medium-dose group (GJM) and low-dose group (GJL) (12.15

8.1

4.05 g · kg-1). Each treatment group was treated with corresponding drug intervention. After treatment

their body weight and fasting blood glucose (FBG) were measured per week

and serum samples were taken 24 h after the last administration. Then the differencesin blood lipid[total cholesterol (TC)

triglyceride (TG)

high-density lipoprotein-cholesterol (HDL-C)

low-density lipoprotein-cholesterol (LDL-C)]

serum liver enzyme activity[aspartate aminotransferase (AST)

alanine aminotransferase (ALT)]

blood urea nitrogen (BUN)

serum creatinine (SCr)

and blood uric acid (UA) were compared between groups. Result: As compared with N group

the body weight was decreased in rats of the MOD group

and FBG

LDL-C

ALT

AST

BUN

SCr and UA levels were all increased

while HDL-C level was decreased (P<0.05). As compared with MOD group

the body weight was increased in various treatment groups

and the FBG

LDL-C levels were decreased (P<0.01); meanwhile

ALT

UA levels were significantly decreased in MET group

GJH group and GJM group (P<0.05). As compared with MET group

the body weight was decreased in GJH group and GJL group

and LDL-C level was significantly decreased (P<0.05); meanwhile

the FBG

ALT

and UA levels were increased in GJL group (P<0.05)

while the TC and LDL-C levels were decreased in GJM group (P<0.01). As compared with GJM group

the body weight was decreased in GJH and GJL groups

and the levels of FBG

and LDL-C were increased (P<0.05); meanwhile

ALT and UA levels were increased in GJL group (P<0.01). Conclusion: Different doses of Gegen Jiaotaiwan can reduce the blood lipid and blood glucose levels of T2DM rats

increase the body weight of rats

inhibit ALT expression

and reduce UA content

which could be used to control T2DM and its complications.

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