Objective: To study the clinical efficacy of Bushe Huatan Yizhi decoction combined with butylphthalide and effect on oxidative stress

hemorheology and cognitive function in patients with Alzheimer's disease (AD). Method: The 127 patients with AD treated in The Third Affiliated Hospital

Qiqihar Medical College from March 2014 to April 2016 were selected in this study and divided into two groups according to the random number table

with 63 cases in treatment group and 64 cases in control group. Patients in control group were treated with butylphthalide soft capsules

and on this basis

the patient in treatment group were given with additional Bushe Huatan Yizhi decoction. After 3 months treatment

the treatment efficacy

oxidative stress

hemorheology and mini-mental state examination (MMSE) scores were compared. Result: The total effective rate was 93.65% in treatment group

higher than 81.25% in control group (P<0.05). After treatment

the hematocrit

the whole blood viscosity at low shear rate

whole blood viscosity

erythrocyte aggregation index were decreased significantly in both groups

and the levels in treatment group were lower than those in control group (P<0.05). As compared with the conditions before treatment

the levels of malonyldialdehyde (MDA) were decreased while super oxide dismutase (SOD)

glutathione peroxidase (GSH-Px) and catalase (CAT) were increased in both groups after treatment

and the effect was more obvious in treatment group (P<0.05). After treatment

MMSE scores and the scores of memory

attention

computational power

orientation

language ability

and recall ability were improved in both groups

and the effects were more obvious in treatment group (P<0.05). Conclusion: Bushe Huatan Yizhi decoction combined with butylphthalide can significantly improve cognitive function and hemorheology

and lower oxidative stress levels in patients with AD

so it has positive therapeutic effect on AD.