Objective: In this study

we researched the stability of rhubarb anthraquinones in artificial gastric juice and synergistic effect of its enteric preparation

in order to provide reference for rational application of Rhei Radix et Rhizoma. Method: Water decoction of Rhei Radix et Rhizoma was placed in the artificial gastric juice

and the content of rhubarb anthraquinones was analysed at 0.5

1

2 h

respectively.After decoction of Rhei Radix et Rhizoma

rhubarb traditional granules and enteric granules were prepared by spray drying

and then we compared their differences in efficacy of purgaion. Result: After 2 h when water decoction of Rhei Radix et Rhizoma placed in the artificial gastric juice

the content of Rhubarb combined anthraquinones destroyed about 23.868 mg

and the content of total anthraquinones destroyed about 16.966 mg

the content of free anthraquinones increased by about 6.902 mg;the content of combined anthraquinones with purgative effect decreased by about 25%.Compared with the same dose of rhubarb traditional granules group

the defecation volume of rhubarb enteric granules group in 12 h was significantly increased. Conclusion: Rhubarb anthraquinones is unstable in the gastric juice

especially the combined anthraquinones.Rhubarb enteric preparation can avoid anthraquinones being hydrolyzed in the stomach

and enhance its purgative effect.