Lycii Fructus polysaccharide extracted from the fruit of Lycium chinense is one of the most active chemicals of Lycii Fructus

and has multiple pharmacological functions

such as enhancing immunity

anti-oxidation

anti-aging

inhibiting tumor

protecting retina

liver and nervous system

and sugar and lipid-decreasing effects. Many studies have demonstrated that Lycii Fructus polysaccharide was widely used to treat various diseases in clinic

such as tumor and immune diseases

hypertension and hyperlipidemia

acute liver injury

cerebral ischemia and apoplexy. Because Lycii Fructus polysaccharide has a significant efficacy in relieving central nervous system diseases

such as Alzheimer's disease and cerebral ischemia

its application in physical nervous system has attracted more and more attention. In recent years

studies on the neuroprotective effect of Lycii Fructus in central nervous system have been increased. To further promote the studies on the prevention and treatment of central nervous system diseases

this review systematically summarizes the neuroprotective effect of Lycii Fructus polysaccharide based on domestic and foreign reports for the effects of Lycii Fructus polysaccharide in alleviating neurodegenerative disease

protecting optic nerve

inhibiting oxidative stress

apoptosis and inflammatory response

reducing glutamate toxicity

and inhibiting the abnormal differentiation of nerve stem cells. However

because the neuroprotective mechanisms of Lycii Fructus Polysaccharide are complicated and not very clear in some aspects

we shall define the mechanisms of neuroprotective action of Lycii Fructus Polysaccharide with modern molecular biology techniques and gene analysis methods

which may provide useful theoretical support to further studies.