Objective: To observe the effect of modified Qiju Dihuang Tang based on syndrome differentiation in treating patients with hypertensive disorder complicating pregnancy (syndrome of hyperactivity of liver due to Yin deficiency) at preeclampsia and cytotoxic factor-vascular endothelial function. Method: One hundred and sixty patients were randomly divided into control group(80 cases) and observation group(80 cases) by random number table. Patients in control group were injected with 25% magnesium sulfate (10 mL) and 5% glucose (100 mL) for successively 7 days

and orally given labetalol hydrochloride tablets

100 mg/time

3 times/days. In addition to the therapy of control group

patients in observation group got modified Qiju Dihuang Tang based on syndrome differentiation

1 dose/day. The treatment continued until the day before termination of pregnancy. And the outcome of pregnancy was recorded

and the cumulative incidence of spontaneous abortion

hypertensive heart disease complicating pregnancy

placental abruption

oligohydramnios

postpartum hemorrhage and dead were calculated. And the cumulative incidence of stillbirth

neonatal respiratory distress syndrome

low body weight after birth

asphyxia of newborn and neonatal death were also recorded. Before and after treatment

the blood pressure level and syndrome of hyperactivity of liver due to Yin deficiency were evaluated

and levels of interleukin-6 (IL-6)

tumor necrosis factor-α (TNF-α)

serum cystatin C(CysC)

neuropeptide Y (NPY)

serum endothelin-1 (ET-1)

nitric oxide (NO)

homocysteine (Hcy)

von Willebrand factor (vWF) were detected. Result: The cumulative incidence rate of adverse pregnancy outcomes in pregnant women in observation group was 13.16%

which was lower than 76.92% in control group (χ2=6.940

P<0.01). The premature birth rate in observation group was 15.79%

which was lower than 25.64% in control group. The term delivery rate in observation group was 78.95%

which was higher than 62.82% in control group (χ2=4.626

P<0.01). The cumulative incidence rate of fetal adverse outcomes in control group was 32.05%

which was higher than 17.11% in observation group (χ2=4.626

P<0.05). After treatment

levels of SBP and DBP in observation group were lower than those in control group

and scores of syndrome of hyperactivity of liver due to Yin deficiency was lower than that in control group (P<0.01). Levels of IL-6

TNF-α

CysC

NPY

ET-1

vWF and Hcy were lower than those in control group (P<0.01). The total effect rate of disease in observation group was 94.74%

which was higher than 83.33% in control group (χ2=5.097

P<0.05). Conclusion: In addition to the therapy of routine western medicine

modified Qiju Dihuang Tang based on syndrome differentiation can control blood pressure of patients

relieve clinical symptoms

reduce maternal and infantile adverse outcomes

improve the comprehensive treatment effect

ameliorate vascular endothelial function and relieve injury caused by cytotoxic factor.