Objective: To study the chemical constituents from the aerial parts of Scutellaria amoena. Method: The aerial parts of S. amoena were extracted by using 90% ethanol heat refluxing method

then suspended in H2O and partitioned with ethyl acetate and n-butanol to obtain respective fractions. The components were isolated and purified by silica gel chromatography

polyamide chromatography

Sephadex LH-20 column

recrystallization and other methods. Their chemical structures were identified on the basis of physicochemical properties and spectral analysis (1H-NMR

13 C-NMR and MS). Result: Eleven compounds were isolated from 90% ethanol extracts and identified as baicalein (1)

baicalin (2)

oroxylin A (3)

oroxylin A-7-O-β-D-glucurunopyranside (4)

wogonin (5)

norwogonin (6)

chrysin (7)

chrysin-7-O-β-D-glucurunopyranoside (8)

scutellarin (9)

5

7-dihydroxy-6

8-dimethoxyflavone (10)

and β-sitosterol (11). Conclusion: All compounds were isolated from the aerial parts of S. amoena for the first time. Compounds 9 and 10 were isolated from this plant for the first time.