Objective: To explore the therapeutic effect and mechanism of action modified Huanglian Ejiao Tang in treatment the post-stroke insomnia of Yin-deficiency and fire-hyperactivity syndrome. Method: A total of 156 eligible patients were randomly divided into control group and treatment group

with 78 cases in each group. The control group was orally given Eszopiclone and Anmian Bunao oral liquid

and the treatment group was given modified Huanglian Ejiao Tang and Eszopiclone. A course of treatment was 2 months. Pittsburgh sleep quality index scale (PSQI)

barthel of daily life activities ability evaluation (Barthel)

nerve function defect symptoms rating scale (NDS) and traditional Chinese medicine (TCM) scale for post-stroke Yin-deficiency and fire-hyperactivity syndromes between two groups were compared before and after treatment. Serum interleukin-6 (IL-6)

calcitonin gene-related peptide (CGRP)

dopamine (DA) and lipid peroxidated (LPO) were detected before and after treatment. The effective rate

recurrence rate and adverse reaction rate were compared in two groups. Result: Six cases were lost in control group

and 2 cases were lost in treatment group. The efficiency of the treatment group was 98.7%

which was better than 87.5% of control group (P<0.05). After treatment

the score of PSQI

Barthel

NDS and TCM symptom in the treatment group were improved more obviously (P<0.05). The improvement of serum IL-6

CGRP

DA and LPO in treatment group was superior to that in control group (P<0.05). The recurrence rate and adverse reaction rate in treatment group were lower than those in control group (P<0.05). Conclusion: Modified Huanglian Ejiao Tang treatment has a significant efficacy in treating post-stroke insomnia with Yin-deficiency and fire-hyperactivity syndrome

and its mechanism of action may be related to the improvement of PSQI

Barthel

NDS

TCM syndromes and the content of serum IL-6

CGRP

DA and LPO.