Objective: To study the clinical efficacy of Bushen Yifei Huaxian decoction on lung function

inflammatory mediator and quality of life in patients with chronic obstructive pulmonary disease (COPD) complicated with pulmonary fibrosis (PF). Method: The study selected 146 cases of patients with COPD-PF treated in Hebei Province Hospital of Traditional Chinese Medicine from May 2014 to July 2016.They were divided into two groups according to the random number table

with 73 cases in each group. Patients in the control group were treated with Salmeterol assigned powder inhaler

while the clinical group was also given Bushen Yifei Huaxian decoction in addition to the therapy of control group. Then the efficacy

lung function

inflammatory mediator and quality of life were compared after 3 months of treatment. Result: Compared with 82.19% in control group

the total effective rate of the clinical group was 93.15%. There was a significant increase (χ2=16.412

P<0.05). Compared with before treatment

tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) of two groups decreased after treatment (P<0.05). Compared with control group

the values of TNF-α and IL-6 in patients of the clinical group were lower after treatment (P<0.05). Compared with before treatment

forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) of the two groups after treatment increased (P<0.05). Compared with control group

the values of FEV1 and FVC in patients of the clinical group were higher after treatment (P<0.05). After treatment

scores of symptom

activity ability

disease influence and total scores in treatment group were lower than those in control group. There was a significant increase (P<0.05). Conclusion: Bushen Yifei Huaxian decoction is very effective in treating COPD-PF. It can significantly lower inflammatory mediators

and improve lung function and quality of life.