Objective: To discuss the effect of Yupingfeng San combined with governor meridian long-snake moxibustion on serum interleukin-6 (IL-6)

cyclic adenosine monophosphate (cAMP)

cyclic guanosine monophosphate (cGMP) in patients with allergic rhinitis (AR). Method: A total of 100 patients with AR treated from June 2013 to June 2016 in Henan Province Hospital of Traditional Chinese Medicine were selected. According to the treatment method

all of the patients were divided into long-snake moxibustion group and Yupingfeng group

with 50 cases in each group.Long-snake moxibustion group was given cetirizine + governor vessel long-snake moxibustion treatment

Yupingfeng group on the basis was given Yupingfeng granules treatment

Serum IL-6

cGMP

cAMP levels were detected by enzyme-linked immunosorbent method. Before and after treatment

serum IL-6

cGMP

cAMP levels

sneezing

runny nose

stuffy nose

nasal itching disappearance time

efficacy

adverse reaction

recurrence of all of the patients were analyzed. Result: After treatment

serum IL-6

cGMP levels of Yupingfeng San group and long-snake moxibustion group were significantly lower than those before treatment; after treatment

serum IL-6

cGMP levels of Yupingfeng group were significantly lower than those of long-snake moxibustion group; after treatment

serum cAMP level of Yupingfeng group was significantly higher than that of long-snake moxibustion group

with statistically significant differences (P<0.05). Sneezing

runny nose

stuffy nose

nasal itching disappearance time of Yupingfeng group were significantly lower than those of long-snake moxibustion group; therapeutic response rate of Yupingfeng group was significantly higher than that of long-snake moxibustion group

with statistically significant differences (P<0.05) but no serious adverse reaction in the two groups. The recurrence rate of Yupingfeng San group was significantly lower than that of long-snake moxibustion group

with statistically significant differences (P<0.05). Conclusion: Yupingfeng San combined with governor meridian long-snake moxibustion can effectively improve the short-term and long-term efficacy of patients with AR

which may be related to more effective regulation of body immune function. It has a good safety

and is worth further clinical promotion.